In addition, DR3/4 siblings who share both HLA haplotypes identical by descent with their diabetic DR3/4 sibling are at a higher risk than those sharing 1 or no haplotypes (13).
0302 and are identical by descent for both HLA haplotypes with their diabetic proband sibling were observed to have a 65% risk for developing islet autoantibodies by age 7 years and a 50% risk of developing diabetes by age 10 years (13).
The COP measures the degree of genetic relatedness among genotypes based on pedigree information by estimating the probability that a random allele from one genotype is identical by descent
to a random allele of another genotype at the same locus (Kempthorne, 1969).
A co-ancestry (or kinship) coefficient is the probability that an allele randomly drawn from one individual is identical by descent
(autozygous) within the pedigree to an allele drawn from another individual and is equivalent in value to the inbreeding coefficient for these individuals' prospective offspring (Hartl and Clark 1989).
1 The high probe density provides broad coverage of constitutional, cancer, OMIM and RefSeq genes on a single array and allows detection of gene-level, copy-neutral LOH, uniparental isodisomy, and regions identical by descent
Therefore, Princess-77 and SWI-11 are 50% identical by descent
F is the probability that the two alleles at the same locus in an individual are identical by descent
It is the probability that the two alleles at a locus are identical by descent
for a random plant in Cycle i.
A proportion, r, of the genes of cross-fertilizing relatives are identical by descent
from a common ancestor.
COP quantifies the intensity of relatedness between pairs of cultivars, expressed as the probability that a random allele from a random locus in one cultivar is identical by descent
to a random allele present at that same locus in the second cultivar (Cox et al.
t]) is the probability that two genes from two different males (females) in generation t are identical by descent
and y, the same probability for two genes, one each from a male and a female in generation t.
The coefficient of parentage (COP), which measures the probability of alleles in two individuals being identical by descent
, has been used extensively to indirectly assess diversity within germplasm pools.