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A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.


Pediatrics A clinical trial–Inhaled Nitric Oxide Study which evaluated the effect of NO therapy–NOT in hypoxic respiratory failure–HRF in neonates. See Respiratory distress syndrome.
References in periodicals archive ?
The secondary antibodies, a horseradish peroxidase-linked sheep anti-rabbit immunoglobulin G (IgG) for iNOS, [sz]-actin (KPL, USA) and a horseradish peroxidase-linked sheep anti-mouse IgG for nNOS, eNOS (KPL, USA), were both incubated at 1:3000 dilution in blocking solution at room temperature for 1.
Macrophages and myoblasts in chickens can express iNOS (Lin et al.
iNOS is rarely expressed in normal tissue and its expression occurs in response to cytotoxin, endotoxin, tumour cells or inflammatory cells participating in pathologic procedures.
Preliminary examination of Kaplan-Meier survival curves demonstrated that, in this study, patients with fibrotic NSIP, septal iNOS <17.
Evidences show that iNOS activity has positive correlation with tumour progression by stimulation of angiogenesis and increased mutagenesis which makes this molecule a therapeutic target for the treatment of cancer.
Adrian Parry-Jones, sales director at family-owned Fifth Wheel, said: "The Inos has attracted a lot of interest from across the continent and especially in Germany.
Stop STAT1 and STAT3 and you break the chain that leads to COX2 and iNOS - and the growth of lung tumours along with them.
Increased iNOS expression and a consequent increase in tissue nitrite and nitrate production have been observed in the kidneys and liver of SCD patients (8), mice (2), (3), (8), (9), and pigs (4).
INOS is an isoform of NOS and its expression is seen in a wide variety of cells such as macrophages, hepatocytes, and keratinocytes and is induced by sev-eral agents as LPS and cytokines and has the ability to synthesize large amounts of NO.
Aminoguanidine; cimetidine; lipopolysaccharide (LPS) derived from Escherichia coli; monoclonal mouse anti-[beta]-actin clone AC-15; mouse iNOS, TNF-[alpha] and [beta]-actin oligonucleotide primers; precision plus dual protein standards and all other chemicals were purchased from Sigma-Aldrich (USA).
11-18) In patients with allergic rhinitis, increased iNOS expression caused by the release of proinflammatory cytokines in the upper and lower respiratory tract mucosae has emerged as a possible cause of increased NO levels.