hypoxic drive


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hypoxic drive

[-hīpok′sik]
stimulation of respiration by low PaO2, mediated through the carotid and aortic bodies.
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2] levels above 60 mmHg, even at rest at sea level in normal subjects the hypoxic drive can be detectable in some patients so that it is advisable to eliminate any possible hypoxic drive by maintaining the PaC[O.
In case of poor distribution of ventilation, five minutes prior to the test the patient is given 50 percent 02 and balance N2 to exclude complications from an increased residual volume and possible hidden hypoxic drive.
Patients relying on hypoxic drive to stimulate adequate ventilation may be tipped into respiratory failure if administered supplementary oxygen.
For decades, the Hypoxic Drive Theory has influenced the care of patients with COPD.
This low oxygen level eventually stimulates the peripheral chemoreceptors, and the patient with COPD is said to be breathing by virtue of the hypoxic drive.
A hypoxic drive accounts for 10% to 15% of the total respiratory drive (Whitnack, 2001).
This has led to the assumption that the hypoxic drive has been obliterated and the movement of air has diminished.
However, although the Hypoxic Drive Theory cannot be completely discounted in all C[O.
Classic thinking was that this was due to long term depression of the hypoxic drive.
Although hypoxic (low levels of oxygen) drive is minimal or non existent with PaO2 levels above 60 mmHg, even at rest at sea level in normal subjects the hypoxic drive can be detectable in some patients so that it is advisable to eliminate any possible hypoxic drive by maintaining the PaO2 above 160 mmHg with high levels of oxygen in the gas mixture.
Blood gas monitoring in these patients becomes especially important to prevent knocking out their hypoxic drive.

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