hypoxia-inducible factor


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hypoxia-inducible factor

A factor within aerobic cells that helps them adapt to abnormally low oxygen concentrations.
See also: factor
References in periodicals archive ?
The company applies its pioneering expertise in hypoxia-inducible factor (HIF), connective tissue growth factor (CTGF) biology, and clinical development to advance innovative medicines for the treatment of anemia, fibrotic disease, and cancer.
Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor currently in global Phase 3 development for the treatment of anemia due to CKD.
Hypoxia-inducible factors as essential regulators of inflammation.
Taylor et al., "Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia," The Journal of Experimental Medicine, vol.
One of the major mechanisms of IRI involves pathways downstream of the transcription factor Hypoxia-Inducible Factor (HIF).
Laughner et al., "Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases," Cancer Research, vol.
Semenza, "General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia," Proceedings of the National Academy of Sciences of the United States of America, vol.
Burk, "Downregulation of integrins by von Hippel-Lindau (VHL) tumor suppressor protein is independent of VHL-directed hypoxia-inducible factor alpha degradation," The International Journal of Biochemistry & Cell Biology, vol.
Huang, "Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia," The Yale Journal of Biology and Medicine, vol.

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