hypoxia inducible factor


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hypoxia inducible factor

Any of a number of transcription factors (e.g., HIF-1alpha) which activate transcription of genes to produce proteins that increase oxygen delivery by stimulating erythropoiesis and angiogenesis, and triggering adaptation to low oxygen environment (e.g., by stimulating glycolysis or mediating apoptosis).
References in periodicals archive ?
Renal hypoxia inducible factors (HIF) and STAT3 cross-talk in vivo (Abstract #F-FC184)12 Hypoxia response is likely shaped by combined action of several transcription factors, including HIF and STAT3.
Oncothyreon's PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a Phase 1 trial in patients with advanced metastatic cancer and lymphoma.
PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many other proteins including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and activator protein 1 (AP-1).
PX-478 is a novel small molecule compound designed to inhibit the activity of hypoxia inducible factor (HIF)-1 alpha, a transcription factor that controls the expression of a number of genes important for growth and survival of cancer cells.
PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many transcription factors including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and activator protein 1 (AP-1).
Semenza, MD, PhD Director, Vascular Program; Professor, Pediatrics, Medicine, Oncology, Radiation Oncology -- Johns Hopkins University School of Medicine "Novel Regulators and Targets of HIF-1" Giovanni Melillo, MD Senior Investigator -- National Cancer Institute at Frederick "Targeting the Tumor Microenvironment: Small Molecule Inhibitors of Hypoxia Inducible Factor 1 (HIF-1)" Invited speakers and presentation topics include: Paolo M.
Panzem works through multiple mechanisms of action (MOA), including inhibiting angiogenesis, disrupting microtubule formation, down regulating hypoxia inducible factor one-alpha (HIF-1a), and inducing apoptosis (cell death).
The three lead compounds, designed and developed by EntreMed scientists, have anti-tumor activities including the ability to induce apoptosis, target microtubules and inhibit hypoxia inducible factor 1 (HIF-1).
The Mitochondria and the Hypoxia Induced Gene Expression Mediated by the Hypoxia Inducible Factors