hypoxanthine phosphoribosyltransferase

(redirected from hypoxanthine guanine phosphoribosyltransferase)

hy·po·xan·thine phos·pho·ri·bo·syl·trans·fer·ase

an enzyme present in human tissue that catalyzes the conversion of hypoxanthine and guanine to their respective 5' nucleotides, with 5-phosphoribose 1-diphosphate as the ribose-phosphate donor; a partial deficiency of this enzyme can result in elevated purine biosynthesis leading to gout; another level of deficiency is associated with Lesch-Nyhan syndrome.
References in periodicals archive ?
The hypoxanthine guanine phosphoribosyltransferase gene was used as an internal control (primers for the PCR can be found at http://sps.
6]-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes.
Description(a) Symbol (a) Hypoxanthine guanine phosphoribosyltransferase Hprt (b) Growth arrest and DNA-damage-inducible 45 gamma Gadd45g Cytochrome P450, 2a4 (c) Cyp2a4 Major urinary protein-1 Mup1 RIKEN cDNA 0610010A22 gene 0610010A22Rik Cytochrome P450, steroid inducible 3a11 Cyp3a11 E4F transcription factor-1 E4f1 Cytochrome P450, 7b1 Cyp7b1 Glutathione S-transferase, pi 2 Gstp2 Ferritin light chain-1 Ftl1 NADPH-P450 (cytochrome) oxidoreductase Por Description(a) Accession no.