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secondary amenorrhea arising from defective hypothalamic stimulation of the anterior lobe of the pituitary.
Etymology: Gk, hypo + thalamos, chamber
cessation of menses caused by disorders that inhibit the hypothalamus from initiating the cycle of neurohormonal interactions of the brain, pituitary, and ovary necessary for ovulation and subsequent menstruation. Examples of causes are stress, anxiety, and acute weight loss. See also amenorrhea.
Amenorrhea related to interference with release of gonadotropin-releasing hormone (GnRH) or with pituitary release of follicle-stimulating hormone or luteinizing hormone. Hypothalamic dysfunction may be drug-induced, e.g., related to abuse of marijuana or tranquilizers; psychogenic, e.g., related to chronic anxiety; functional, e.g., related to excessive exercise, anorexia, or obesity; or related to chronic medical illness, head injuries, or cancer.
See also: amenorrhea