hypothalamic amenorrhea


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to hypothalamic amenorrhea: hypothalamus, Hypothalamic dysfunction

hy·po·tha·lam·ic a·men·or·rhe·a

secondary amenorrhea arising from defective hypothalamic stimulation of the anterior lobe of the pituitary.

hypothalamic amenorrhea

[-thalam′ik]
Etymology: Gk, hypo + thalamos, chamber
cessation of menses caused by disorders that inhibit the hypothalamus from initiating the cycle of neurohormonal interactions of the brain, pituitary, and ovary necessary for ovulation and subsequent menstruation. Examples of causes are stress, anxiety, and acute weight loss. See also amenorrhea.

hypothalamic amenorrhea

Amenorrhea related to interference with release of gonadotropin-releasing hormone (GnRH) or with pituitary release of follicle-stimulating hormone or luteinizing hormone. Hypothalamic dysfunction may be drug-induced, e.g., related to abuse of marijuana or tranquilizers; psychogenic, e.g., related to chronic anxiety; functional, e.g., related to excessive exercise, anorexia, or obesity; or related to chronic medical illness, head injuries, or cancer.
See also: amenorrhea
References in periodicals archive ?
DHEAS levels were normal in women with anorexia nervosa not receiving contraceptives and in women with hypothalamic amenorrhea.
Free testosterone levels were found to be predictors of bone mineral density and body composition in women with anorexia nervosa, hypothalamic amenorrhea, and healthy controls.
Ringham and her colleagues had previously demonstrated that women with functional hypothalamic amenorrhea are distinguishable from women having as organic cause for their amenorrhea as well as from normally menstruating women on the basis of their high levels of subthreshold symptoms of disordered eating, with dysfunctional attitudes, mild undernutrition, and/or excessive energy output.
She reported on 14 normal-weight women who met stringent criteria for functional hypothalamic amenorrhea, including an absence of psychiatric conditions, eating disorders, or pituitary tumors.
Ahima said that the decrease in leptin levels during fasting--which mediates the suppression of reproductive, growth, and thyroid hormones, increases glucocorticoids, and stimulates food intake--may have evolved as a defense against starvation, which hypothalamic amenorrhea closely resembles.
Preclinical studies in monkeys had demonstrated that psychological stress and mild metabolic imbalances act synergistically in inducing functional hypothalamic amenorrhea, Dr.