Clinical examination at 5 years of age noted some dysmorphic features such as prominent forehead, big ears, hypotelorism
, downslanted palpebral fissures, epicanthus, strabismus, depressed nasal root, anteverted nares, long philtrum, and malar flattening.
(2) Cebocephaly represents the combination of hypotelorism
and a blind-ended single nostril.
The physical exam found fused sutures, posterior and anterior fontanelle < 1 cm, rounded face, sinophris, ocular hypotelorism
, cebocephaly, single nostril, micrognathia, flat osseous palate, and pectus excavatum (Figure 3).
He had hypotelorism
, slightly up-slanted palpebral fissures, long lashes, an exaggerated bow on the upper lip, and a short upturned nose.
However, a number of studies demonstrate that CP is a human teratogen due to its effects such as intrauterine growth retardation and multiple anomalies including microbrachycephaly, coronal craniosynostosis, hypotelorism
, shallow orbits, proptosis, blepharophimosis, abnormal and small ears, unilateral preauricular pit, broad, flat nasal bridge, microstomia, high-arched palate, micrognathia, cranial anomalies, preaxial upper limb and post-axial lower limb defects consisting of hypoplastic thumbs, and oligodactyly like bilateral absence of 4th and 5th toes (Enns et al., 1999).
(5,11) Ocular Hypotelorism
(close-set eyes), cyclopia (single median eye) and micrognathia are all facial abnormalities associated with trisomy 13.
A total of 37 patients had metopic synostosis, demonstrating the characteristic trigonocephalic shape and various aspects of bitemporal narrowing and hypotelorism
. Of these, 22 were male and 15 were female.
Physical examination was signifcant for hypotonia, non-specifc dysmorphic facial fndings including slight frontal bossing, hypotelorism
, low nasal bridge and anteverted nares.
Her face was round, no hypotelorism
, caries teeth, and small chin.