hyposplenism

hyposplenism

 [hi″po-splen´izm]
diminished functioning of the spleen.

hy·po·splen·ism

(hī'pō-splēn'izm),
Absent or reduced splenic function, usually due to surgical removal, congenital aplasia, tumor replacement, or splenic vascular accident. Red blood cell abnormalities, including the presence of inclusions, nucleated red blood cells, and target cells, are commonly present. Patients with hyposplenism are at increased risk of bacterial sepsis, especially due to infection by Pneumococcus.

hyposplenism

/hy·po·splen·ism/ (-splen´izm) diminished functioning of the spleen, resulting in an increase in peripheral blood elements.

hy·po·splen·ism

(hī'pō-splēn'izm)
Absent or reduced splenic function, usually due to surgical removal, congenital aplasia, tumor replacement, or splenic vascular accident.

hyposplenism

diminished functioning of the spleen, resulting in an increase in peripheral blood elements.
References in periodicals archive ?
The blood film was otherwise unremarkable; in particular, no evidence for hyposplenism was found.
Functional hyposplenism due to a primary epithelioid hemangioendothelioma of the spleen.
polycythaemia vera), various malignancies and hyposplenism.
In particular, hyposplenism renders patients more susceptible to the detrimental effects of encapsulated organisms and malaria.
Chronic complications of untreated CD include lymphoma and adenocarcinomas of the jejunum, recurrent miscarriages, neurologic disorders, osteoporosis, and hyposplenism.
Hyposplenism was assessed by abdominal ultrasound and peripheral blood smear findings, osteoporosis was assessed by dual x-ray absorptiometry, cardiovascular complications were assessed by echocardiogram and multi-gated acquisition scan, hepatitis C virus infection was determined by detection of anti-hepatitis C virus antibodies and hepatitis C virus RNA by polymerase chain reaction (PCR), and renal impairment was assessed by measuring creatinine clearance.
Persistent thrombocytosis raised the possibility of Hyposplenism which was confirmed by peripheral smears and radiological investigations.
3) The major cause of death in celiac disease associated with cavitary lymph nodes and splenic atrophy is overwhelming infection complicated by hyposplenism and cachexia.
1 This increased suscep-tibility to infections is related to abnormalities in the defense mechanisms of these patients, including functional hyposplenism,2 an abnormality in the alternative pathway of complement activities,3 and defective neutrophil function.