Histologic diagnosis identified one case of SCOS, 38 of maturation arrest (MA), and five of hypospermatogenesis
(HS) among infertile patients with Y microdeletion.
Three cases had normal spermatogenesis, two cases had hypospermatogenesis, two cases had maturation arrest, two cases had testicular atrophy and sertoli cell syndrome on histopathology, in one case the biopsy was inadequate.
Four cases with diagnosis of hypospermatogenesis on biopsy 2 cases presented with azoospermia.
Male rats exposed in utero to di(n-butyl) phthalate (DBP) exhibit numerous reproductive tract defects, including decreased anogenital distance (AGD), formation of multinucleated germ cells (MNG), hypospermatogenesis
, underdeveloped or absent reproductive organs, cryptorchidism, and hypospadias (Gray et al.
These cases, however, are best classified as hypospermatogenesis with a heterogeneous pattern, a topic detailed in a subsequent section.
Other clues to hypospermatogenesis include an increased number of small-caliber tubules, and, due to the associated disruptions in the architecture of germ cell maturation, earlier stages of germ cell development may be shed into the lumen.
Although patients with hypospermatogenesis
returned the best results, sperm recovery and oocyte fertilisation are possible, even in cases where no spermatozoa were found in testicular biopsy.
Histological analysis showed a severe hypospermatogenesis
in all patients.
5%); and tubular hyalinization plus some groups of tubules with hypospermatogenesis
(1 testis, 4.
In a previous study from our laboratory, we documented that raised ROS levels lead to both mitochondrial sequence variation and nuclear DNA damage, which results in impaired motility and hypospermatogenesis
which may be the underlying pathology in infertility and RSA (6, 7).
10) However, any mutation in mitochondrial genome would ultimately affect the production of ATP, consequently may lead to abnormal spermatogenesis, impaired differentiation and hypospermatogenesis
However, deletion of only AZFc region is found to be associated with a wide range of phenotypes ranging from hypospermatogenesis
to SCO II (isolated foci of spermatogenesis along with Sertoli cells) syndrome (9).