A: In one of our studies, we determined the reproductive hormones and morphological changes induced by mobile phone radiation and found that long-term exposure to mobile phone radiation leads to reduction in serum testosterone levels and cause hypospermatogenesis
and maturation arrest in the spermatozoa in the testis of albino rats.
BACKGROUND: In utero exposure to endocrine-disrupting chemicals may contribute to testicular dysgenesis syndrome (TDS), a proposed constellation of increasingly common male reproductive tract abnormalities (including hypospadias, cryptorchidism, hypospermatogenesis, and testicular cancer).
Male rats exposed in utero to di(n-butyl) phthalate (DBP) exhibit numerous reproductive tract defects, including decreased anogenital distance (AGD), formation of multinucleated germ cells (MNG), hypospermatogenesis, underdeveloped or absent reproductive organs, cryptorchidism, and hypospadias (Gray et al.
In a group of 135 men, sperm were found in 51% of men with Sertoli-cell-only pattern, 83% in men with maturation arrest, and 100% of men with hypospermatogenesis.
These cases, however, are best classified as hypospermatogenesis with a heterogeneous pattern, a topic detailed in a subsequent section.
First, the production of spermatozoa may not be enough to trigger apoptosis in men with hypospermatogenesis
In a previous study from our laboratory, we documented that raised ROS levels lead to both mitochondrial sequence variation and nuclear DNA damage, which results in impaired motility and hypospermatogenesis
which may be the underlying pathology in infertility and RSA (6, 7).
In the cases where late pachytene substages were observed in this group, failure of spermatogenesis appeared as hypospermatogenesis
, with a reduction of all stages from spermatogonia to spermatids.
5%); and tubular hyalinization plus some groups of tubules with hypospermatogenesis
(1 testis, 4.
10) However, any mutation in mitochondrial genome would ultimately affect the production of ATP, consequently may lead to abnormal spermatogenesis, impaired differentiation and hypospermatogenesis
However, deletion of only AZFc region is found to be associated with a wide range of phenotypes ranging from hypospermatogenesis
to SCO II (isolated foci of spermatogenesis along with Sertoli cells) syndrome (9).