There was significant improvement in hyposmia
after turbinectomy (71.43%) and also after turbinoplasty (71.43%).
Chen et al., "Hyposmia
correlates with SNCA variant and non-motor symptoms in Chinese patients with Parkinson's disease," Parkinsonism & Related Disorders, vol.
Kallmann syndrome is usually a clinical diagnosis defined by the presence of idiopathic hypogonadotropic hypogonadism and anosmia or hyposmia
. Additional abnormalities that may aid in the early diagnosis of the disease including synkinesia (KAL1), dental agenesis and bony anomalies (FGF8/FGFR1 or KAL2), hearing loss (CHD7, SOXIO), renal agenesis, and cleft lip and palate [reviewed in ].
Berendse, "Idiopathic hyposmia
as a preclinical sign of Parkinson's disease," Annals of Neurology, vol.
In total, 30 subjects (45.5%) identified a mild to severe impairment of olfactory function, including 21 subjects (31.8%) referring to a reduced sense of smell (hyposmia
): in the case of 9 of them, the olfactory function was reduced but not abolished, and the remaining 12 of them complained about a substantial anosmia (18.2%).
HH may be presented with normal (normosmic HH) (Quinton et al., 2001; Bhagavath et al., 2006) or decreased (hyposmia
) or absent (anosmia) (Kallman Syndrome) sense of smell (Seminara et al., 1998; Fechner and McGovern, 2008).
In 1937, a series of blackouts, preceded by an uncinated crisis characterized by the unpleasant smell of "burned rubber," the diagnosis mentioning a psychosomatic problem with "defense mechanisms" (Zilboorg; qtd by Ruiz & Montanes 2005: 176); migraines attributed to his working too hard, with uncinated crises; nausea, dizziness and olfactory hallucinations-all of this leading to his hospitalization in the Los Angeles "Cedars of Lebanon." Complaints of motor limitations of his right hand, and of motor incoordination-with a diagnosis of "hysteria." Complaints of hyposmia
, persistent migraine, restlessness and new complex partial seizures-hospitalization finding small and unequal pupils, no voluntary movements, failure to react to painful stimuli: i.e.
In this study, 44 IPD patients who did not have dementia in the beginning but had severe hyposmia
were tracked for 3 years.
Clinical symptoms include chronic nasal congestion, nasal discharge, facial pressure, and hyposmia
. CRSwNP is characterized by grape-like structures in the upper nasal cavity that originate from within the ostiomeatal complex.
Parkinson's disease is associated with motor symptoms involving bradykinesia, rest tremor, rigidity, and postural disturbances, in addition to non-motor symptoms including hyposmia
, rapid eye movements, sleep behavior disorder, and depression.
Epidemiological studies suggest that nonmotor symptoms such as hyposmia
(poor sense of smell), chronic constipation, rapid eye movement sleep behavior disorder (in which sufferers appear to act out dreams in their sleep), daytime sleepiness, anxiety, and depression may occur before the appearance of motor dysfunction in PD patients.
We call that anosmia or hyposmia
, the inability to sense smells or a reduced ability to sense smells," Bernier explained.