Hyporeactive (Figure 2): Less well-formed granulomas with areas of necrosis were surrounded by epithelioid histiocytes, although in many cases, histiocytes did not completely encircle the granuloma.
In 2 of the 3 patients with parenchymal infection, hyporeactive inflammatory foci were seen, whereas the patient who had been treated showed well-circumscribed nodules of spindled histiocytes with occasional AFB.
The hyporeactive inflammatory pattern was the most common pattern seen in organs other than the brain, present in 85 of 131 organs examined histologically.