Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti related protein, and alphamelanocyte-stimulating hormone.
These similar results with the present study suggested that the SS1 gene corresponds to the
hypophysiotropic form.
Wurtz et al., "Strategies to convert PACAP from a
hypophysiotropic neurohormone into a neuroprotective drug," Current Pharmaceutical Design, vol.
(8.) Cullinan WE, CABA(A) receptor subunit expression within
hypophysiotropic CRH neurons: a dual hybridization histochemical study, J Comp Neurol.
PACAP and the growth release hormone (GRH) are part of the same super-family of regulatory neuropeptides and both have
hypophysiotropic activity; low height is common in patients with Monosomy 18p and it may be a result of deficiency of the growth hormone secondary to an alteration in a path involving the genes mentioned, where PACAP would be absent because of the deletion (4).
