Also found in: Dictionary, Thesaurus, Encyclopedia.


1. pertaining to the pituitary gland.
3. a preparation of the pituitary glands of animals, used therapeutically.
pituitary gland an endocrine gland located at the base of the brain in a small recess of the sphenoid bone called the sella turcica. It is attached by the hypophyseal stalk to the hypothalamus and is divided into an anterior lobe (the adenohypophysis) and a posterior lobe (the neurohypophysis), which differ in embryological function and origin. Called also hypophysis.

The adenohypophysis originates from epithelial tissue. The adenohypophysis secretes six important hormones: growth hormone, thyroid-stimulating hormone or thyrotropin, adrenocorticotropic hormone or corticotropin, prolactin, follicle-stimulating hormone, and luteinizing hormone. Most of these hormones are tropic hormones, which regulate the growth, development, and proper functioning of other endocrine glands and are of vital importance to the growth, maturation, and reproduction of the individual. Secretion of the anterior pituitary hormones is controlled by releasing and inhibiting hormones produced by the hypothalamus. Information gathered by the nervous system about the well-being of an individual is collected in the hypothalamus and used to control the secretion of hormones by the pituitary gland. The hypothalamic releasing and inhibiting hormones are transported to the pituitary gland by way of the hypothalamic-hypophyseal portal system in which the hypothalamic venules connect with the capillaries of the anterior pituitary.

The neurohypophysis originates from neural tissue; it stores and secretes two hormones, oxytocin and vasopressin (antidiuretic hormone). These hormones are synthesized in the cell bodies of neurons located in the hypothalamus and transported along the axons to the terminals located in the neurohypophysis and are released in response to neural stimulation.

Surgical removal of part or all of the pituitary gland is called hypophysectomy and is usually done for treatment of a pituitary tumor. Because of its influence on the adrenal cortex and other endocrine glands, removal of the pituitary gland has widespread effects on the body. See hypophysectomy.
The pituitary gland and its relationship to the hypothalamus.
posterior pituitary neurohypophysis.


Relating to a hypophysis.
Synonym(s): hypophyseal


/hy·po·phys·e·al/ (-fiz´e-al) hypophysial.


[-fizē′əl, -fiz′ē·əl]
Etymology: Gk, hypo, under, phyein, to grow
pertaining to the hypophysis (pituitary body).

hypophyseal, hypophysial

pertaining to the hypophysis (pituitary).

hypophyseal base
the pars tuberalis and the infundibular stalk of the pituitary gland.
hypophyseal portal system
the vascular anatomy of the pituitary gland which provides the route for hypothalamic regulating hormones to enter and control the secretion of the adenohypophyseal hormones.
hypophyseal system
the hypothalamus, the pituitary gland and the hypophyseoportal circulation.
References in periodicals archive ?
The largest series of patients with hypophyseal abscess, i.
The results of laboratory studies, including hypophyseal function, were normal.
Bone increase is influenced by endocrine factors and vitamins; this is how the hypophyseal growth hormone, parathyroid and thyroid hormones, as well as sexual hormones intervene.
Thyroid dysfunction in uremia; Evidence with thyroid and hypophyseal abnormalities.
Other possible etiologies include vasospasm, thrombosis, and compression of hypophyseal arteries.
In their study however reduction in testicular weight was seen in GnRH antagonist (Gonadotrphin releasing hormone antagonist) implying effect of blockage of hypothalamo hypophyseal gonadal axis.
Then, Thiophanate Methyl can affect the hypothalamic and hypophyseal hormones [27] by disturbing the secretion of GnRH which stimulates adeno-hypophys is to secrete LH and FSH by modifying the receiving sites affecting testosterone secretion [28, 29].
Morphometrical and ultrastructural analyses of hypophyseal cells from adult monkeys fed a protein-restricted diet containing 10% protein have shown a decline in the number of somatotrophic, lactotrophic, gonadotrophic and tireotrophic cells.
This inability could result from injury to the hypothalamus, the supraoptic hypophyseal tract, or the posterior pituitary gland (Hickey, 2003).