FGF23 is being researched in the context of X-linked hypophosphatemic
rickets, mineral bone disorder (MBD), chronic kidney disease (CKD), tumor-induced osteomalacia and hyperphosphatemia.
The firm will use the proceeds from this financing to advance its lead enzyme replacement therapy for the treatment of Generalised Arterial Calcification of Infancy (GACI) and Autosomal Recessive Hypophosphatemic
Rickets Type 2 (ARHR2) into the clinic.
Periapical and endodontic status of permanent teeth in patients with hypophosphatemic
Development of CPPD crystal deposition disease in young people (<55 years) may be associated with metabolic diseases such as hemochromatosis, hyperparathyroidism, hypomagnesemia, Wilson's disease, hypothyroidism, gout, acromegaly, and X-linked hypophosphatemic
Eighty three percent of ventilated children were hypophosphatemic
(n=15 vs n=3).
Syed Zubair Hussain was the next speaker whose presentation was on Hypophosphatemic
rickets and osteomalacia.
Tumour- induced osteomalacia: an important cause of adult-onset hypophosphatemic
osteomalacia in China: Report of 39 cases and review of the literature.
The list of the diseases associated with OPLL includes hypophosphatemic
rickets/osteomalacia, including an autosomal dominant form (MIM 193100) caused by FGF23 mutations, an X-linked dominant form (MIM 307800) caused by PHEX mutations, an X-linked recessive form (MIM 300554) caused by CLCN5 mutations, and autosomal recessive forms caused by DMP1 (MIM 600980) and ENPP1 (MIM 173335) mutations.
However, several novel regulators of phosphate homeostasis have been identified as being associated with hypophosphatemia of various types, such as tumor-induced osteomalacia, several hereditary forms of hypophosphatemic
rickets, X-linked hypophosphatemia, and autosomal dominant hypophosphatemia (1, 3).
In the past, several phenotypic variants of Dent's disease were independently described and named as separate disorders, including X-linked recessive nephrolithiasis with renal failure, X-linked recessive hypophosphatemic
rickets and familiar idiopathic LMW proteinuria with hypercalciuria in Japanese patients .
Liver disease and hypophosphatemic
rickets: Suspect tyrosinemia TYPE-1.
Calcification of entheses associated with X-linked hypophosphatemic