hypophosphatemic

hypophosphatemic

(hī″pō-fŏs″fă-tē′mĭk) [Gr. hypo-, less than, deficient, + L. phosphas, phosphate, + Gr. haima, blood]
1. Having an abnormally low blood phosphate concentration.
2. An agent that lowers the blood phosphate concentration, e.g., in renal failure.
References in periodicals archive ?
One patient was previously followed for hypophosphatemic rickets and treated with calcitriol and phosphate.
(3) In addition to the syndromes described, there are reports of associations between keratinocytic nevi and ILVEN with hypophosphatemic rickets and precocious puberty.
One case of hypophosphatemic osteomalacia was reported in a subject who received 500 mg of Injectafer every 2 weeks for a total of 16 weeks.
Hypophosphatemic VDRR may be less severe when it occurs in the late stages of life and does not cause bone deformity.
The benefit show, which also features Molehill, Jess Godwin and Tall Doug, will raise funds to help defray expenses related to Lewis' medical therapy for a rare degenerative disease called x-linked hypophosphatemic rickets.
INZ-701, the company's lead therapeutic candidate, is in pre-clinical development for the treatment of patients with ENPP1 Deficiency, a serious and life-threatening calcification disorder that manifests as generalized arterial calcification of infancy in infants and as autosomal recessive hypophosphatemic rickets type 2 (ARHR2) post-infancy.
Recent studies revealed that the gene responsible for the regulation of phosphate levels is located on the X chromosome, and mutations in this gene result in hypophosphatemic rickets (3).
FGF23 is being researched in the context of X-linked hypophosphatemic rickets, mineral bone disorder (MBD), chronic kidney disease (CKD), tumor-induced osteomalacia and hyperphosphatemia.
Antibodies against Wnt inhibitors were proven useful to improve bone parameters in animal models of osteoporosis, fracture, and osteomalacia caused by hypophosphatemic rickets, suggesting they could also have a beneficial effect on bone in CKD [55, 56, 78, 140, 141].
The firm will use the proceeds from this financing to advance its lead enzyme replacement therapy for the treatment of Generalised Arterial Calcification of Infancy (GACI) and Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) into the clinic.
Development of CPPD crystal deposition disease in young people (<55 years) may be associated with metabolic diseases such as hemochromatosis, hyperparathyroidism, hypomagnesemia, Wilson's disease, hypothyroidism, gout, acromegaly, and X-linked hypophosphatemic rickets.
Notably, the authors found that FMBD was associated with severe osteomalacia due to mineralization defects predominantly caused by nephrogenic hypocalcemia and hypophosphatemic defects due to renal tubular damage caused by F [210].