Systemic G-CSF attenuates cerebral inflammation and hypomyelination
but does not reduce seizure burden in preterm sheep exposed to global hypoxia-ischemia.
CT A-II is characterized by a generalized shaking of the whole body associated with variable degrees of hypomyelination
in the brain and spinal cord.
The physical examination and laboratory findings of the child (hypotonia, hypertelorism, pes equinovarus, renal cysts, pale optic disc, hypomyelination
, epileptiform discharges in EEG, increased levels of VLCFA: C26:0, C24:0/C22:0, C26:0/C22:0) had been supporting ZS but genetic testing wasn't performed.
Cortical atrophy, cystic changes in white matter and hypomyelination
are detected due to prolonged hyperammonia in OTC deficiency.
The findings in the brain included focal minimal parasagittal and parietal pachygyria, glioneuronal heterotopias, neuronal migrational abnormalities, hypomyelination
of central white matter, and mineralizing lenticulostriate vasculopathy with focal gliosis in basal ganglia and thalamus.
Another category of white matter involvement is hypomyelination
disorders like Pelizaeus-Merzbacher disease.
Diffuse cerebral hypomyelination
with cerebellar atrophy and hypoplasia of corpus callosum.
Magnetic resonance imaging of brain and spine was done and the finding was prominent perivascular space along the corpus callosum due to hypo intensity of the bilateral thalami and posterior limb of internal capsule, peritrigonal hypomyelination
, dysplastic changes of the dense process of C2 with small sinus reaction articulating with anterior C1 ring, abnormal peaking of the upper lumbar vertebrae [Figure 2].
Abnormalities in the central nervous system (periventricular leukoencephalomalacia, most significant on the left side, and the presence of hypomyelination
around the bilateral trigone (S).
Connor, "The mechanism of vanadium-mediated developmental hypomyelination
is related to destruction of oligodendrocyte progenitors through a relationship with ferritin and iron," Neurotoxicity Research, vol.
Conduction slowing provides indirect evidence of myelin dysfunction and is usually considered a sign of demyelination or hypomyelination
Sadie suffers from hypomyelination
and atrophy of the basal ganglia, a rare condition affecting her brain and development.