Alanine participates in cellular bioenergetics, lower levels of which in AD group demonstrates the energetic deficiency and hypometabolism
in AD, which could be related to decreased carbohydrate metabolism and mitochondrial dysfunction (54).
Contralateral cerebellar hypometabolism
(CCH) is a wellestablished remote functional effect related to CCD that might be promoted by the uncoupling of the oxygen consumption and glucose utilization caused by neuronal deafferentation .
Caroli et al., "Cortical sources of resting state EEG rhythms are related to brain hypometabolism
in subjects with Alzheimer's disease: an EEG-PET study," Neurobiology of Aging, vol.
Some authors found in CH patients abnormalities of cerebral glucose brain metabolism, hypometabolism
in the cerebellopontine area, perigenual anterior cingulate cortex, and prefrontal and orbitofrontal cortex during bout and out of bout [4-6].
Hinz et al., "Amyloid, hypometabolism
, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study," Neurology, vol.
Hypertension is associated with worse cognitive function and hippocampal hypometabolism
in Alzheimer's disease," European Journal of Neurology, vol.
de Leon et al., "Hypometabolism
exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease," Journal of Nuclear Medicine, vol.
Hypothyroidism; its aetiology and relation to hypometabolism
, hypercholesterolaemia, and increase in body-weight.
Pathologically, AD shows accumulation of senile plaques, neurofibrillar tangles, brain atrophy, and regional cerebral hypometabolism
with low cerebral metabolic rates of glucose use.
in the inferior frontal lobe in depressed patients with Parkinson's disease.
talpoides, it is reported that the American shrew-mole, Neurotrichus gibbsii, shows body temperature reduction and hypometabolism
along with a reduction of ambient temperature (Campbell & Hochachka 2000).
PET shows hypometabolism
. Reduced background activity, polymorphic delta activity, and epileptiform features are seen in electroencephalogram.