Noncompacted segments are usually hypokinetic
with Color Doppler evidence of flow deep within the intertrabecular recesses (14, 19-20), which predisposes to formation of thrombi, leading to thromboembolic events such as cerebrovascular accidents in 20 to 40% of patients.
Normal pressure hydrocephalus (NPH) is an often overlooked cause of hypokinetic
gait disorders in older adults (Stolze et al., 2000).
The predictors of poor prognosis are an ejection fraction of less than 0.25 (as seen on Echo, during the acute presentation of heart failure), left ventricular end diastolic dilatation, a hypokinetic
left ventricle, the presence of mitral and tricuspid regurgitation.
We conducted a cross-sectional study in 86 participants selected from the EPIMOV Study (Epidemiological Study of Human Movement and Hypokinetic
Diseases) and enrolled 40 men and 46 women from 40 to 74 years of age.
All participants were diagnosed with hypokinetic
dysarthria, which is consistent with the speech profile generally observed in people with PD .
The echocardiogram revealed preserved left ventricular ejection fraction, hypokinetic
RV with RV/LV > 1 and severe pulmonary hypertension (right ventricular systolic pressure of 73 mmHg) (Figure 3).
Echocardiography revealed poor overall systolic function (ejection fraction 45%) with hypokinetic
apical and lateral walls with an apical aneurysm and a mobile thrombus measuring about 3.6 cm x 1.7 cm in the apical region of the left ventricle (Fig.
Echocardiography done in ER showed situs solitus dextrocardia with severely hypokinetic
left ventricular anterior wall and apex and ejection fraction of approximately 40%.
Wall motion was described as normal, hypokinetic
, akinetic or dyskinetic.
For example, a severely hypokinetic
patient may perform finger dexterity relatively fast but virtually without any movement amplitude at all, which renders the outcome measure for bradykinesia (i.e., the time taken to perform the test) inconclusive.
The predictors of poor prognosis,  in our patient were an ejection fraction of 0.15, a hypokinetic
heart, the presence of moderate mitral regurgitation, Tricuspid regurgitation, severe PAH with systolic and diastolic dysfunction.
In contrast, a 2-fold increase in PTU dose led to severe hypothyroidism in the animals, with considerable loss of body weight and a hypokinetic