hypogranulosis

hypogranulosis

decreased thickness of the stratum granulosum.
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Examination of the biopsy specimen obtained from the knee revealed regular acanthosis and hypogranulosis, mild spongiosis, and intraepidermal clusters of neutrophils (Munro's microabscess) in the epidermis, and the diagnosis of psoriasis was confirmed.
There was hypogranulosis or agranulosis in subcornoid lamella region along with mild dyskeratosis and a few vacuolar cells.
Histopathology of skin lesion revealed focal acanthosis, hyperkeratosis and parakeratosis with Munro's microabscesses, hypogranulosis, suprapapillary thinning with focal elongation of rete pegs with sparse perivascular lymphocytic infiltrate which was consistent with psoriasis vulgaris [Figure 3].
Histologic findings that supported the final diagnosis included compact parakeratosis, pallor of the upper epidermis, hypogranulosis, intraepidermal vesiculation, keratinocyte necrosis, and architectural disarray.
The acantholytic cells have homogenised cytoplasm, hyperkeratosis and hypogranulosis.