hypogonadotropic hypogonadism


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Related to hypogonadotropic hypogonadism: hypergonadotropic hypogonadism, primary hypogonadism

hypogonadism

 [hi″po-go´nad-izm]
decreased functional activity of the gonads, with retardation of growth, sexual development, and secondary sex characters. The American Association of Clinical Endocrinologists has published “Clinical Practice Guidelines for the Evaluation and Treatment of Hypogonadism in Adult Male Patients.” These are available online at their web site: http://www.aace.com.
hypergonadotropic hypogonadism that associated with secretion of high levels of gonadotropins, as in Klinefelter's syndrome. Called also hypergonadotropic eunuchoidism.
hypogonadotropic hypogonadism that due to lack of gonads or of gonadotropin secretion. Called also hypogonadotropic eunuchoidism.

hy·po·gon·a·do·trop·ic hy·po·go·nad·ism

[MIM*146110]
defective gonadal development or function, or both, resulting from inadequate secretion of pituitary gonadotropins.

hypogonadotropic hypogonadism

Hypogonadotropic eunuchoidism, Kallman syndrome A rare condition with a highly variable hereditary pattern, characterized by secondary hypogonadism–↓ gonadotropin-releasing hormone due to hypothalamic or pituitary dysfunction with testicular failure, and anosmia–due to hypoplasia or aplasia of the olfactory bulbs and tracts, 2º to a defect in the migration of olfactory neurons, and neurons producing GRH–gonadotropin-releasing hormone; ↓ FSH and LH impairs sperm and androgen production Clinical Delayed puberty, micropenis, eunuchoid features, cryptorchidism, midline defects–eg, cleft lip and palate, unilateral renal agenesis, horseshoe kidney, nerve deafness and hearing loss, color blindness, skeletal abnormalities; synkinesia, spatial attention defects, spastic paraplegia, cerebellar dysfunction, horizontal nystagmus, pes cavus, mental retardation Management Androgens to induce anatomic maturation; gonadotropins or LH-releasing factor for spermatogenesis. See Kalig-1.

hypogonadotropic hypogonadism

A usually congenital condition in which there is a severe deficiency of the gonadotropin-releasing hormone (GnRH) of the pituitary gland. As a rulethe penis remains infantile and the testes do not descend into the scrotum (cryptorchidism). No sexual development occurs at puberty. In rare cases the condition may develop in men who had previous normal secondary sexual development and a normal puberty. This leads to loss of libido, impotence and infertility. In these cases, treatment with gonadotropin-releasing hormone can reverse all the features of the disorder.
References in periodicals archive ?
Clinical value of LHRH exciting test in differential diagnosis of constitutional delayed puberty and male hypogonadotropic hypogonadism.
These results clearly indicate that the initial pattern of hypogonadotropic hypogonadism was reversed after anastrazole administration.
In summary, these results, based on single-point sampling of LH, testosterone, and estradiol concentrations before and after the administration of the aromatase inhibitor anastrazole, indicate alleviation of hypogonadotropic hypogonadism in these patients.
Some of the major causes of delayed puberty are constitutional delay in growth and development, hypergonadotropic hypogonadism and hypogonadotropic hypogonadism (HH) (Geffner, 2002).
The present study examined mutations in GPR54 and GNRHR genes in thirty one sporadic cases of hypogonadotropic hypogonadism with complaints of delayed puberty visiting our public sector hospitals.
Thus, insensitivity to insulin at the hypothalamic level may contribute to the development of hypogonadotropic hypogonadism.
The report provides a snapshot of the global therapeutic landscape of Hypogonadotropic Hypogonadism
The report reviews key players involved in the therapeutics development for Hypogonadotropic Hypogonadism and enlists all their major and minor projects
Low GnRH, low LH, low testosterone indicate the syndrome of Hypogonadotropic Hypogonadism, and it is a downward trend that takes men closer to Andropause.
The deficiency in release or action of GnRH leads to hypogonadotropic hypogonadism (HH) characterized by low follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) and results in absent or impaired sexual development at puberty.
INTRODUCTION: Hypogonadotropic hypogonadism is classified depending on different conditions; isolated deficiency or combined deficiency with other pituitary hormones, congenital or acquired (Adult onset) and hypothalamic or hypophyseal defects.
Differential diagnosis of men with hypogonadotropic hypogonadism includes pituitary disorders, hyperprolactinemia, hemochromatosis, stress, and AIDS.