The serum levels of PSDP, lysoPCs, 3D, 7D, 11D-phytanic acid, behenic acid, hypoglycin B, phytal and threoninyl-a-glutamate were significantly different between the active TB and lung cancer subgroups ( ?
In Muzaffarpur, MCPG is hypothesized to cause acute hypoglycemia and illness through a similar mechanism to hypoglycin A, a toxin that has been reported to cause acute encephalopathy in the West Indies and West Africa after consumption of unripe ackee, a fruit in the same botanical family as litchi (6-9).
Hypoglycin A and B isolated from the fruits of Blighia sapida, which are chemically related to lysine were reported for their anti-hyperglycemic activity (Hassall and Reyle, 1954; Feng and Patrick, 1958).
Hypoglycin A, B: biologically active polypeptides from Blighia sapida.
The toxin is called hypoglycin A and it is present, in varying concentrations, in the leaves and the helicopter-shaped seeds; there is evidence that the weather can affect the level of toxin produced by the tree and not all seeds contain the same level.
There is no antidote for hypoglycin A poisoning - treatment consists of managing the effects of the poison on the body, flushing out the horse's system and maintaining hydration to prevent further damage.
Unripe ackee contains hypoglycin A, a water-soluble liver toxin that induces hypoglycemia by inhibiting gluconeogenesis secondary to its limiting of cofactors (CoA and carnitine) essential for oxidation of long-chain fatty acids ( 1,4 ).