hypoglycemic agent


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hypoglycemic agent

any of various synthetic drugs that lower the blood glucose level and are used to treat type 2 diabetes mellitus. They may stimulate synthesis of insulin by pancreatic beta cells, inhibit glucose production, facilitate transport of glucose to muscle cells, and sometimes increase the number of receptor sites where insulin can be bound and can initiate the process of breaking down glucose. Most are sulfonylureas, including acetoHEXAMIDE, chlorproPAMIDE, glipiZIDE, TOLAZamide, and TOLBUTamide. Patients should be advised that these drugs are not a cure for diabetes but only a means of controlling it and that it is important to continue to comply with dietary and exercise prescriptions.

hy·po·gly·ce·mic a·gent

(hī'pō-glī-sē'mik ā'jĕnt)
Oral medications used in the management of Type 2 diabetes mellitus, but ineffective in Type 1 diabetes.
References in periodicals archive ?
Among the subjects, 44 patients were on oral hypoglycemic agents, 16 had been on insulin therapy for at least 5 years and 40 were on oral hypoglycemics as well as insulin therapy.
All subjects maintained their usual diabetes therapy which consisted of the oral hypoglycemic agents sulfonylurea and/or metformin.
Crouch studied 73 similar patients, who were also on hypoglycemic agents and no exogenous insulin.
Type 2 diabetes was defined in terms of treatment by diet or with oral hypoglycemic agents, alone or with insulin.
potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica.
Other oral hypoglycemic agents now under study for possible use in pregnancy include metformnin and acarbose.
Chlorpropamide, used as the standard hypoglycemic agent in this study, is a member of the 'first-generation' sulphonylureas.
Fischette also was responsible for Phase IV strategic development, roll-out and launch of clinical programs for a newly approved oral hypoglycemic agent, and for all aspects of clinical and non-clinical drug development programs for FDA approval involving CNS drugs and Glucotrol XL[R], among others.
Thiazolidinedione Combinations Used to Treat Diabetes TZD, plus oral hypoglycemic agent 48% TZD, plus oral hypoglycemic agent, plus insulin 36% TZD, plus insulin 10% TZD only 6% Note: Based on data from 22,709 patients who had taken TZDs to treat type 2 diabetes.
Glimepiride is also indicated for use in combination with insulin to lower blood glucose in patients whose hyperglycemia cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent.