Insulin detemir is associated with more predictable glycaemic control and lower risk of hypoglycaemia
compared to NPH in subjects with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart.
Persons at risk of hypoglycaemia
need to anticipate and suspect hypoglycaemic episodes, so that preventive and immediate corrective measures can be done.
Regarding hypoglycaemic episodes, 44% of the elderly diabetics had hypoglycaemia
as compared to 14% in those below 50 years.
After a review of evidence, the European Commission has said that the driving ban for people experiencing recurrent severe hypoglycaemia
when asleep should be lifted.
This was achieved at an increased risk of hypoglycaemia
and greater weight gain than in the conventionally treated group (Table 2).
This was, however, a small study, investigating whether dogs could detect hypoglycaemia
scent on the skin from samples obtained from participants who were not known to the dogs.
, insulintreated patients with diabetes had an approximately 60 percent higher risk of cardiovascular events, and were twice as likely to die over the same period as patients who did not experience hypoglycaemia
, the findings showed.
Professors Kamlesh Khunti and Melanie Davies, scientists from the University of Leicester's Diabetes Research Centre, have confirmed an association between hypoglycaemia
and an increased risk of cardiovascular events and mortality in insulin-treated patients with diabetes, which could lead to changes in the way some patients' treatment is managed.
Heptares, in partnership with the University of Manchester and Great Ormond Street Hospital, London, will then conduct the preclinical development of candidates with the aim of providing novel safe, effective and orally available molecules for clinical studies for congenital hyperinsulinism with anticipated additional potential in other areas associated with intractable hypoglycaemia
; including neonatal hypoglycaemia
occurring as a consequence of gastric bypass surgery and insulinoma-associated hypoglycaemia
7] Therefore, in sick children presenting to the emergency room, reliance on clinical manifestations to detect hypoglycaemia
may result in missed diagnosis with attendant increase in the risk of complications of hypoglycaemia
typically occurs within the first 3 days of fluoroquinolones therapy and has been reported after the first dose of either intravenous or oral administration.
At the same time it is known that severe hypoglycaemia
is a potential risk factor for cardiovascular disease in type 2 diabetics, although the association is controversial and the possible effects of co-morbidity have not been fully investigated.