deficiency in the number of myenteric ganglion cells in the distal segment of the large bowel, resulting in constipation; a variant of congenital megacolon.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


A reduction in the number of ganglionic nerve cells.
Farlex Partner Medical Dictionary © Farlex 2012


A reduction in the number of ganglionic nerve cells.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
(3) However, chronic intestinal pseudo-obstruction encompasses enteric visceral myopathy, neuropathy, and mesenchymopathy, and it may be associated with well-established histopathology, including fibrotic or vacuolar degeneration of the muscularis propria, inclusions, hypoganglionosis, and inflammation.
Oligoneuronal hypoganglionosis in patients with idiopathic slow-transit constipation.
There was no problem/ controversy regarding diagnosis of aganglionosis but when we talk of ganglionic segments actually it may include the normal number of ganglion cells and allied HDs, which are hypoganglionosis, hyperganglionosis and immature ganglion cells.
Miyano, "Pathophysiology of hypoganglionosis," Journal of Pediatric Gastroenterology and Nutrition, vol.
Malformations in the reserved segment are mainly type B intestinal neuronal dysplasia and hypoganglionosis.[sup][70],[71]
Patterns of postoperative enterocolitis in children with Hirschsprung's disease combined with hypoganglionosis. J Pediatr Surg 2009;44:1401-4.
Discussion includes characteristics of classical and ultrashort Hirschsprung's disease; total intestinal aganglionosis and hypoganglionosis; new diseases like intestinal neuronal dysplasia, desmosis coli, leiomyopathy, architectural malformation, and stretching lesions of muscularis propria; and atrophic desmosis.
(2-4) This paper reports a patient with a history of cerebrovascular accident presenting with sigmoid volvulus secondary to megacolon with hypoganglionosis. The clinical data lend further credence to the possible etiologic association between the adult dysmotility diseases and cerebrovascular injury.
Although the overwhelming likely hood is that the marked hypoganglionosis was a consequence of the central nervous system disease, other possible etiologies needed to be considered.
Other neuronal abnormali ties included isolated hypoganglionosis, immaturity of ganglion cells and isolated hyperganglio nosis (IND Type B).
Key words: Hirschsprung's disease (HD), hypoganglionosis, hyperganglionosis (IND type B) and immaturity of ganglion cells (IGC).
Total colonic aganglionosis is often associated with a long transition zone characterized by hypoganglionosis and the presence of abnormal immature cells individually and in clusters.