deficiency in the number of myenteric ganglion cells in the distal segment of the large bowel, resulting in constipation; a variant of congenital megacolon.


A reduction in the number of ganglionic nerve cells.


/hy·po·gan·gli·o·no·sis/ (-gang″gle-on-o´sis) lessened number of myenteric ganglion cells in the distal large bowel, with constipation; a congenital type of megacolon.


A reduction in the number of ganglionic nerve cells.

hypogangliosis, hypoganglionosis

deficiency in the number of myenteric ganglion cells, usually in the colon leading to the development of megacolon. See also aganglionosis.

Clydesdale myenteric hypogangliosis
megacolon develops at about 4-9 months old. Possibly an inherited trait.
References in periodicals archive ?
There was no problem/ controversy regarding diagnosis of aganglionosis but when we talk of ganglionic segments actually it may include the normal number of ganglion cells and allied HDs, which are hypoganglionosis, hyperganglionosis and immature ganglion cells.
Malformations in the reserved segment are mainly type B intestinal neuronal dysplasia and hypoganglionosis.
Patterns of postoperative enterocolitis in children with Hirschsprung's disease combined with hypoganglionosis.
Total colonic aganglionosis is often associated with a long transition zone characterized by hypoganglionosis and the presence of abnormal immature cells individually and in clusters.
2-4) This paper reports a patient with a history of cerebrovascular accident presenting with sigmoid volvulus secondary to megacolon with hypoganglionosis.
Although the overwhelming likely hood is that the marked hypoganglionosis was a consequence of the central nervous system disease, other possible etiologies needed to be considered.
Megacolon in an adult case of hypoganglionosis, a pseudo-Hirschsprung's disease: an autopsy study.
Other neuronal abnormali ties included isolated hypoganglionosis, immaturity of ganglion cells and isolated hyperganglio nosis (IND Type B).
Key words: Hirschsprung's disease (HD), hypoganglionosis, hyperganglionosis (IND type B) and immaturity of ganglion cells (IGC).
Congenital intestinal neuronal disturbances have been classified as aganglionosis (Hirschsprung's di sease), hyperganglionosis (Intestinal Neuronal Dys plasia), hypoganglionosis, ganglion cell immaturity, combined forms and certain unclassifiable forms.
8 Almost all cases reported in literature occurred relatively late in chil dhood9 and the common complaint of the patients with hypoganglionosis is intractable constipation.