Again, the high Hb [A.sub.2] level was discordant with minimal or absent microcytosis and hypochromia
. In this case, we were able to rule out common confounding factors such as folate, vitamin B12 or iron deficiency, thyroid dysfunction, or medication effects.
The Hb Lepore carriers display a [beta]-thalassemic phenotype with microcytosis and hypochromia
. Hb analysis shows 5%-15% of Hb Lepore and increased HbF levels that in most cases do not exceed 5%.
Urrechaga, "Red blood cell microcytosis and hypochromia
in the differential diagnosis of iron deficiency and [beta]-thalassaemia trait," International Journal of Laboratory Hematology, vol.
The most common form is hypochromia
(when the central pallor exceeds one third of the entire red cell diameter).
 Globin synthesis studies and DNA analyses were performed in donors with microcytosis or hypochromia
or both associated with normal ferritin, Hb [A.sub.2] and Hb F levels.
Moreover, microscopic examination of blood films obtained from naturally infected cases showed presence of parasite and various morphological changes in cells such as stomatocyte, hypochromia
in the affected eye resulting from diffuse pigment loss is the key feature of FUS.
(5,6) Also noted in the PBS image is poikilocytosis, anisocytosis, hypochromia
, drepanocytes (sickle cells), and codocytes (target cells).
Laboratory findings in iron deficiency Complete blood count: RDW>14 RBC: low Hb, Hct: low according to age and gender MCV: low according to age and gender When specifying the lower limit of MCV: 70+age (for >10 years) (if MCV is <72, generally abnormal) Upper limit of MCV: 84 + age x 0,6 (for >6 months) (if MCV>98: always abnormal) MCH<27 pg MCHC<30% Thrombocytosis Rarely: Thrombocytopenia, leukopenia Peripheral smear: Hypochromia
Microcytosis Anisochromia Anisocytosis Pencil cells Rarely: bazophilic stippling, target cells, hypersegmented neutrophils Serum ferritin<12 ng/mL (a) Serum iron: <30 mcg/dL (a) TIBC>480 mcg/dL Transferrin saturation (Iron/TBCx100)<16% Metzner index (MCV/RBC)<13 (a) May change by age, gender and other factors.
Thus, our results showed that IDA in patients with RA is characterized by RBC microcytosis and hypochromia
, a reduction in serum iron and ferritin levels, and an increase in serum transferrin and erythropoietin concentrations (Table 2).
Microcytosis was defined as MCV value less than 80 fL and hypochromia
was defined as MCHC value less than 32 g/dL.
The blood smear showed microcytosis, hypochromia
, teardrop cells, and target cells.