Rather than hypercholesterolemia in high risk patients, we have found
hypocholesterolemia HDL to be very high in our study population and this was the most common abnormality found in 44.3% of the patients.
Nuriman, "
Hypocholesterolemia is associated negatively with hemolysate lipid peroxidation in sickle cell anemia patients," Clinical and Experimental Medicine, vol.
Chen, "Primary and secondary
hypocholesterolemia," Beijing Da Xue Xue Bao, vol.
--Other factors like heavy alcohol use,
hypocholesterolemia (< 150 mg/dl cholesterol) -(3 cases; 2%)
Adjusting age and with further segregation of total cholesterol levels into seven groups in a univariate general linear model showed higher mean platelet volume at both extremes of cholesterol i.e.,
hypocholesterolemia (less than 4.5 mmol/L) and hypercholesterolemia (greater than 6.0 mmol/L).
Hu et al., "
Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats," Phytomedicine, vol.
Bisht et al., "Reduced circulating oxidized LDL is associated with
hypocholesterolemia and enhanced thiol status in Gilbert syndrome," Free Radical Biology and Medicine, vol.
Altered high density lipoprotein metabolism in patients with myeloproliferative disorders and
hypocholesterolemia. Metabolism.
(1993) reported that oral administration of TFG seed extract (10 and 100 mg/day per 300 g body weight) enhanced feed intake with motivation to eat in rats and also induced hyperinsulinemia and
hypocholesterolemia. Petit et al.
The present study showed no significant correlation between serum Mn and lipid profile parameters in the two groups, although another study has demonstrated that Mn enhanced cholesterol synthesis in the liver and
hypocholesterolemia has been reported in a human case of Mn deficiency; (26) however, the cause of this finding is probably due to no significant difference in Mn between the two groups.
Breslow et al16 pointed out poor nutritional status, weight loss, depletion of the triceps skinfold, hypoalbuminemia,
hypocholesterolemia and low levels of hemoglobin/hematocrit as independent risk for development of PU.
Thus
hypocholesterolemia leads to non-detoxification of endotoxins and lipopolysaccharides resulting in metabolic syndrome x, neuronal degnerations and autoimmune disease [10-17].