This study shows that the ZDF rat, which displays oxidative-nitrosative stress, MNCV and SNCV deficit, thermal and mechanical hypoalgesia
, small sensory nerve fiber degeneration, and a mild atrophy of large myelinated fibers, is a robust animal model for studying the manifestations and treatment of DPN in type 2 diabetes.
As well as the hypoalgesia
, elevated BP evoked by psychological stress has also being considered as a risk marker of hypertension or coronary diseases (Gerin et al.
The interaction between exercise duration and intensity are believed to both influence the onset of hypoalgesia
during and following exercise (26).
When significant stump dislocation was present, hypoalgesia
was identified in 146 patients (74.
These studies provide the first evidence that targeting molecular chaperones reverses the sensory hypoalgesia
associated with DPN," the authors wrote.
The repetitive application of passive motion seems likely to stimulate endogenous pain control systems at several levels of the central nervous system with many studies showing consistent responses of concurrent hypoalgesia
, sympathetic nervous system excitation and changes in motor function (Schmid et al 2008), as well as a reduction in spinal hyperexcitability (Sterling et al 2010).
It is known that arterial hypertension is associated to hypoalgesia
in animals (22, 23) and humans (24).
Long-term caloric restriction leads to significant hypoalgesia
The prolonged NRM stimulation also produced thermal hypoalgesia
lasting at least 2 weeks in noninjured animals.
Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia
that depends on early activation of the camp pathway.
and opiod inhibition of pigs.
in the rat: Effects of conditioned odors, naltrexone, and extinction.