Towards an in vitro model of Plasmodium hypnozoites
suitable for drug discovery.
It is easier to appreciate the feasibility of this straightforward explanation than to imagine what the mechanistic basis of a homologous hypnozoite
relapse postulation for renewed parasitaemia might be.
IV Pre-erythrocytic schizonts and/or hypnozoites
of Chesson and North Korean strains of Plasmodium vivax in the chimpanzee.
Plasmodium vivax is not fatal, though it is responsible for considerable morbidity in those populations where it is endemic through hypnozoites
(the dormant parasite stages in liver) causing relapse within weeks to months after primary episode (2).
vivax invariably in the form of dormant hypnozoites
malariae despite liver hypnozoites
not being found (13,14).
vivax infections are characterized by relapse of malaria due to persistent latent forms in liver called as hypnozoites
Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites
Ovale malaria may relapse months or years after exposure due to the presence of hypnozoites
in the liver of which the longest reported incubation period for P.
Malaria control strategies have had limited success and are confounded by varying numbers of relapses occurring at different intervals as a result of activation of dormant liver-stage hypnozoites
after the initial infection1.
may give rise to malaria episodes even years after exposure.