Diffusion-weighted and gradient echo magnetic resonance findings of hemichorea-hemiballismus associated with diabetic hyperglycemia: A hyperviscosity
It is thought that hyperglycemia-induced decrease in gamma-aminobutyric acid (GABA) levels (2), hyperviscosity
, and vascular insufficiency lead to incomplete, transient dysfunction in the striatum and results in chorea (3).
induced by hyperglycemia then causes a disruption of the blood-brain barrier and a resulting transient ischemia of the vulnerable striatal neurons .
Other complications, common in MM, such as hyperviscosity
, renal failure, and hypercalcemia can also cause CNS symptoms, most commonly disorientation and somnolence.
In this situation, the RVO and comparison groups were 1: 5 matched using the PS matching method  for age, gender, index year (the year of the index date in the RVOs and the enrollment date in the comparisons), use of antithrombotic drugs, obesity, diabetes, hypertension, hyperlipidemia, coronary artery disease, atrial fibrillation, chronic kidney disease, hyperviscosity
syndrome, Charlson comorbidity index (CCI), and glaucoma.
syndrome secondary to a myelomaassociated IgG(1) kappa paraprotein strongly reactive against the HIV-1 p24 gag antigen.
Guidelines also warn against the risks of adverse transfusion events in these patients, including iron overload, hemolysis, hyperviscosity
, and most important for this discussion, the risk of alloimmunization to foreign RBC antigens.
Risk factors may include: advanced age, prolonged immobilisation, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling vascular catheters, hyperviscosity
, and cardiovascular risk factors.
It reduces the hemoglobin S (HbS) rate, brings normal hemoglobin without increasing the hemoglobin rate where hyperviscosity
is a risk, and decreases iron overload [2, 8].
Patti et al., "Increased plasma apolipoprotein levels and blood hyperviscosity
in non-insulin-dependent diabetic patients: role of the occurrence of arterial hypertension," Acta Diabetologica Latina, vol.
Possible mechanisms include increased hyperviscosity
due to dehydration, stasis, and decreased intracardiac blood flow [11-13].
Depending on the CML phase and biology, patients may have a profoundly elevated WBC at diagnosis, which can present as leukostasis, or hyperviscosity