While the new hypervirulent
variant was first seen exclusively in the Pacific Rim, it has now been found in several cities in North America, including Buffalo, and in Europe, Canada, Israel and South Africa as well.
In another study, investigators at the University of Guelph (Ont.) found evidence of seasonality for contamination of retail meats by hypervirulent
strains of C.
pneumoniae isolates from cryptogenic pyogenic liver abscesses were confirmed to be hypervirulent
In addition, hypervirulent
strains that produce more toxin due to disruptions in the toxin regulatory elements have been associated with more severe disease in some studies as well as with more efficient transmission.
Much of the recent increase in the incidence and mortality of CDIs is attributed to the emergence and spread of a hypervirulent
, resistant strain of C.
Lead researcher Brendan Wren from the London School of Hygiene and Tropical Medicine and his colleagues compared the genomes of three strains of the bacterium, the hypervirulent
'027' strain, an historic, non-epidemic 027 strain and one less related and also non-epidemic '630' strain.
Notably, lineages IIa and IIb have the greatest overlap with the putatively hypervirulent
clade 8 (34), making their segregation of particular concern.
The increase was attributable mainly to the emergence of a new, hypervirulent
strain of BI/NAP1/027, which emerged in 2003 in North America and 2005 in Europe, respectively.
Several countries in Europe, South America, and Australia are experiencing outbreaks of group W meningococcal (MenW) disease, caused by a hypervirulent
strain of Neisseria meningitides belonging to sequence type 11 (ST11) clonal complex (CC) and associated with severe disease and a high case-fatality rate (1).
(1,2) Serious complications such as sepsis, toxic megacolon, need for colectomy, and death are associated with CDI especially in those patients infected by hypervirulent
The recent deaths of 11 people in a Canadian hospital have been attributed to a hypervirulent
strain of Clostridium difficile.