hypervariable region


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hypervariable region (HVR)

a region of a GENOME that is made up of a variable number of repeated sequences and is diagnostic for an individual. See FINGERPRINTING (2).

hypervariable region

regions present on light and heavy chains of immunoglobulins where most of the variation in amino acid sequences occurs. These are also sites of antigen binding.
References in periodicals archive ?
To test this, we considered a large genetic data set of two hypervariable regions (V5 and V6), from previously generated barcoded 16S ribosomal (rDNA) amplicons from microbialite communities distributed in different geographical regions of Mexico.
In Colombia, vaccines with Massachusetts (Mass), Connecticut (Conn) e Arkansas strains are permitted to marketing (6), and even then, the disease is not being controlled, probably because the vaccine strain does not induce cross-protection to different genotypes that have emerged in the field with point mutations and deletion events insertion in the hypervariable region S1 (4).
Full length Hexon carries type, group and subgroup specific antigenic determinants, whereas, hypervariable region of hexon contains type specific antigenic regions.
Additionally, we present the mutational changes (polymorphic sites of the mtDNA) of hypervariable region I at different positions in the sequence to determine founding haplogroups.
18) Recently, a cohort of oral cancers and premalignant oral lesions matched with normal contralateral tissue sites from the same patient were profiled by sequencing 16S rDNA hypervariable region amplicons.
Identification of T-helper and linear B epitope in the hypervariable region of nucleocapsid protein of PPRV and its use in the development of specific antibodies to detect viral antigen.
In that study, we sequenced the 37f hypervariable region of the SSU rDNA exclusively found among foraminifera (Pawlowski and Lecroq, 2010).
Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: Application to the apolipoprotein B 3' hypervariable region.
Located along the var and rif genes, stevor genes are more conserved in comparison but the hypervariable region of STEVOR has significant sequence diversity in different P.
The revelation appears in a Channel 4 documentary, 'Dead Famous DNA,' broadcast next week, in which leading scientists sequenced the hypervariable region of the mitochondrial DNA (mtDNA) from a sample of hairs that was extracted from a monogrammed hairbrush discovered at the end of the WWII War in Braun's apartment at Hitler's Alpine residence, the Berghof in Bavaria, by a US army intelligence officer, the Independent reported.
The spa typing is based on sequencing of the polymorphic x region of protein A and depends on PCR amplification of this hypervariable region.
Despite the fact that most of the variability in the chicken mtDNA hypervariable region can be found in the 201 bp fragment previously studied, longer ancient samples were used in this analysis to address the concerns of critics that the DNA sequences provided in the 2007 study were too short to reliably compare them with longer modern sequences (Gongora et al.