('Acasti or the 'Company') (NASDAQ: ACST - TSX-V: ACST), a biopharmaceutical innovator focused on the research, development and commercialization of its prescription drug candidate CaPre (omega-3 phospholipid) for the treatment of severe hypertriglyceridemia
, today provided a business update and announced its operating and financial results for the first quarter of fiscal 2020 ended June 30, 2019.
Jan D'Alvise, president and CEO of Acasti Pharma, commented, "Our TRILOGY Phase 3 trials in patients with severe hypertriglyceridemia
continue to progress, and we remain on track to report topline TRILOGY 1 results in December 2019, and topline TRILOGY 2 results in January 2020.
Vascepa was initially approved in July 2012 as an adjunct to diet to reduce triglyceride levels in adult patients with severe hypertriglyceridemia
, or very high triglycerides.
CaPre is designed to treat hypertriglyceridemia
, a condition characterized by elevated triglyceride levels in the blood.
It is indicated as an adjunct to diet for the treatment of adult patients with hypertriglyceridemia
, as an adjunct to diet for the treatment of adult patients with primary dysbetalipoproteinemia (type III hyperlipoproteinemia), and as an adjunct to other lipid-lowering treatments (eg, LDL apheresis) or as monotherapy if such treatments are unavailable, to decrease LDL-C, total cholesterol, and ApoB in adult patients with homozygous familial hypercholesterolemia.
One retrospective cohort study reported an 8.5% (8/95) prevalence of eruptive xanthomas in patients with severe hypertriglyceridemia
(ie, triglyceride levels >1770 mg/dL).
has been reported as an etiologic factor in 3-5% of cases with acute pancreatitis (1).
Fish oil is among the most common natural supplement for treatment of hypertriglyceridemia
or prevention of cardiovascular disease.
The company is pursuing treatments for sickle cell disease, short bowel syndrome, and severe hypertriglyceridemia
(2) Complications associated with DKA include cerebral edema, acute kidney failure, acute respiratory distress syndrome, and, rarely, severe hypertriglyceridemia
. (3) Hypertriglyceridemia
is an uncommon cause of acute pancreatitis linked to 1% to 4% of cases.
Diagnosis of acute pancreatitis secondary to hypertriglyceridemia