How activated DNA damage checkpoint signaling contributes to syndrome phenotypes and HSPC hypersusceptibility
to apoptosis will be assessed.
Mutant mtDNA at 1555 A to G in 12S rRNA gene hypersusceptibility
of mitochondrial translation to streptomycin can be co-transferred to rho O HeLa cells.
Aposhian also offered testimony seeming to support a theory of "genetic hypersusceptibility
," which means that some individuals may be genetically predisposed to immune system damage from ethylmercury.
Clinical studies have shown that hypersusceptibility
to HIV drugs is a significant predictor of the magnitude of HIV reduction and increase in CD4 T cells in patients who have failed one or more previous antiretroviral regimens.
The K65R mutation in reverse transcriptase confers resistance to tenofovir and intermediate levels of cross-resistance to abacavir, didanosine, and lamivudine, and also has resistance effects for stavudine (not evident in phenotypic testing), while conferring hypersusceptibility
to cisplatin carcinogenicity in metallothioneinI/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.
It infiltrates the skin rapidly without feeling greasy or tacky, causing no irritation or hypersusceptibility
Generally, the biologic price to pay for extending the substrate range of this enzyme is hypersusceptibility
to [beta]-lactamase inhibitors.
And now we have a third version of the story, which is if you use atazanavir first and get rebound, you actually get hypersusceptibility
of the virus to other protease inhibitors--meaning that the virus is more susceptible to the drugs (at least predicted, based on the mutations seen).
Another phenomenon that has generated a great deal of interest is the opposite case, where some virus strains exhibit increased susceptibility to NNRTIs compared with wild-type virus, often termed hypersusceptibility
Working with the manufacturer, researchers from the California Collaborative Treatment Group tested 164 patients and detected NNRTI hypersusceptibility
Dutch Scientists Found Mother May Help Infants to Prevent Hypersusceptibility
by Eating Organic Milk