Trotti and colleagues have previously shown that most patients with central hypersomnolence
have abnormal potentiation of GABA-A receptors in their cerebrospinal fluid (CSF).
and oculomotor disturbances are often present .
cogwheel rigidity, drooling, dystonia, extrapyramidal disorder, hypokinesia, muscle rigidity, oculogyric crisis, oromandibular dystonia, parkinsonism, psychomotor retardation, tongue spasm, torticollis, tremor and trismus **Somnolence includes adverse event terms: hypersomnia, hypersomnolence
, sedation, and somnolence
Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence
. Sleep 1991; 14:226-232.
The classic neonatal presentation of OTC involves an apparently healthy male neonate who develops feeding difficulties, lethargy and hypersomnolence
within the early neonatal period that rapidly progresses to life-threatening hyperammonaemic encephalopathy.
Fenik et al., "Long-term intermittent hypoxia in mice: protracted hypersomnolence
with oxidative injury to sleep-wake brain regions," Sleep, vol.
OSA is a serious disorder that has been implicated in extreme daytime hypersomnolence
, functional impairment, and automobile accidents.
Overestimation of sleep latency by patients with suspected hypersomnolence
. Sleep 1996;19:94-100.
* Dyssomnias: A broad category of sleep disorders characterised by either hypersomnolence
(33) All muscle relaxants are limited by side effects of fatigue and hypersomnolence
In primary CSA, daytime hypersomnolence
is less common than with OSA, although such daytime sleepiness has been commonly described in patients with central apnoea (74).
According to these guidelines, NIPPV can be considered in stable COPD when: Symptoms (fatigue, morning headache, daytime hypersomnolence
) and one of the following: 1.