Functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism: loss of TSH hypersecretion, hypersomatotropism
, hypoprolactinemia, and pituitary enlargement with transdifferentiation.
Most common endocrine abnormality documented in our series was hypersomatotropism
(20%) (5) and hyperprolactinemia (20%) followed by hyperthyroidism (15) (8%), hypophosphatemia (16) (4%) and precocious puberty (4%).
Forms of endocrine hyperfunction reported in association with MAS include precocious puberty, hyperthyroidism, hypercortisolism, hypersomatotropism
, and hypophosphatemic rickets (1-3).