The most consistent 5HT related finding in autistic disorder is hyperserotonemia (Janusonis, 2008).
Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes.
Although both hyperserotonemia
and hyposerotonemia can induce ASD-like phenotypes in animal models of ASD, these findings also support the treatment potential associated with the serotonin pathway.
Segal, "Effects of developmental hyperserotonemia
on the morphology of rat dentate nuclear neurons," Neuroscience, vol.
has been observed in 25-40% of children and adolescents with autism (Aldred 2003, Kidd 2003).
The issue of hyperserotonemia
and platelet serotonin exposure: a preliminary study.