hypersensitivity syndrome

environmental disease

Fringe medicine
A hypothetical polysymptomatic condition attributed by so-called “clinical ecologists” to immune dysregulation induced by contaminants (e.g., allergens and chemicals, including pesticides and petrochemicals) present in the air, water, food and soil that cause poor nutrition, infection, hereditary factors, and physical and psychological stress, resulting in various physical and mental disorders. Clinical ecologists believe that the immune defects caused by environmental disease lead to mood and thought disorders, psychotic episodes and fatigue; vaguely defined gastrointestinal, respiratory and urinary tract symptoms; rashes; arthritis-like symptoms; and cardiac arrhythmias. Psychiatric disorders (e.g., depression, anxiety and somatisation) are reported to be 2.5-fold greater in those with environmental disease, suggesting that the condition is not entirely organic in nature.

The mainstream medical community is largely skeptical of the existence of environmental disease, given the plethora of symptoms attributed to it, the lack of consistent laboratory abnormalities and the use of unproven therapies to treat it. The concepts and practices of environmental medicine (clinical ecology) have been evaluated by several professional bodies, including the American Academy of Allergy and Immunology; all have concluded that environmental disease has not been proven to exist and that environmental medicine (clinical ecology) is not a valid discipline.

Environmental disease cannot be diagnosed by standard allergy tests or other standard examinations; clinical ecologists use a test of unproven validity known as neutralisation.
Differential diagnosis
Allergies, early diabetes, chronic otitis media, infectious mononucleosis, nasal polyps, respiratory tract infections, sinusitis, thyroid disease and other conditions may mimic environmental disease, and if misdiagnosed and treated incorrectly, will delay more effective (mainstream) therapy.
Avoidance of environmental pollutants, chemicals and pesticides; consumption of organic foods; changing residence or place of employment; nutritional supplements; antifungal agents; hormones; gamma globulin; inhalation of pure oxygen; drinking urine.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

hypersensitivity syndrome

A severe idiosyncratic reaction to certain drugs–eg, anticonvulsants, sulfonamides, allopurinol, which is characterized by rash–eg, exfoliative dermatitis and fever, and may be accompanied by arthralgias, carditis, hepatitis, lymphadenopathy Lab Atypical lymphocytes, eosinophilia, abnormal LFTs
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS).
In a retrospective study, elevated elafin, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha levels were significantly associated with a greater risk of all-cause mortality among hospitalized cancer patients who developed SCARs, which includes Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug-induced hypersensitivity syndrome.
Singer and Wallace had established Allopurinol Hypersensitivity Syndrome criteria for evaluating allopurinol-related reactions (8).
When she is diagnosed with electromagnetic hypersensitivity syndrome (EHS), she has to go offline because she is allergic to gadgets and Wi-Fi.
But then she experienced bleeding of the nose and then diagnosed with Electromagnetic Hypersensitivity Syndrome (EHS).
They include: drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome; Stevens-Johnson syndrome (SIS); toxic epidermal necrolysis (TEN); and pustular psoriasis.
The other rare reactions include dapsone hypersensitivity syndrome (DHS), Stevens--Johnson syndrome or toxic epidermal necrolysis, exanthematous eruption, agranulocytosis, pneumonitis, and nephritis.
Subsequently, it was determined that fever, LNE, and rash developed in relation with carbamazepine and the term 'anticonvulsant hypersensitivity syndrome' was proposed (2).
This is an evolving story about zoster that we never knew about."Drug-induced hypersensitivity syndrome (DIHS) is also associated with CNS manifestations, but they resolve much faster, unlike those of CNS zoster.
Drug hypersensitivity syndrome (DHS) is often reported in patients treated with aromatic antiepileptic drugs and in rare cases with azathioprine [9].