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Related to hypersensitivity: Hypersensitivity pneumonitis


a state of altered reactivity in which the body reacts with an exaggerated immune response to a foreign agent; anaphylaxis and allergy are forms of hypersensitivity. The hypersensitivity states and resulting hypersensitivity reactions are usually subclassified by the Gell and Coombs classification. adj., adj hypersen´sitive.
contact hypersensitivity that produced by contact of the skin with a chemical substance having the properties of an antigen or hapten.
delayed hypersensitivity (DH) (delayed type hypersensitivity (DTH)) the type of hypersensitivity exemplified by the tuberculin reaction, which (as opposed to immediate hypersensitivity) takes 12 to 48 hours to develop and which can be transferred by lymphocytes but not by serum. Delayed hypersensitivity can be induced by most viral infections, many bacterial infections, all mycotic infections, and a few protozoal infections (leishmaniasis and toxoplasmosis). The scope of the term is sometimes expanded to cover all aspects of cell-mediated immunity including contact dermatitis, granulomatous reactions, and allograft rejection.
immediate hypersensitivity antibody-mediated hypersensitivity occurring within minutes when a sensitized individual is exposed to antigen; clinical manifestations include systemic anaphylaxis and atopic allergy (allergic rhinitis, asthma, dermatitis, urticaria, and angioedema). The first exposure to the antigen induces the production of IgE antibodies (cytotropic antibodies, reagin) that bind to receptors on mast cells and basophils. Subsequent exposure to the antigen triggers production and release of a diverse array of mediators of hypersensitivity that act on other cells producing symptoms such as bronchospasm, edema, mucous secretion, and inflammation.
hypersensitivity reaction the exaggerated or inappropriate immune response occurring in hypersensitivity, in response to a substance either foreign or perceived as foreign and resulting in local or general tissue damage. Such reactions are usually classified as types I–IV on the basis of the Gell and Coombs classification.


1. Abnormal sensitivity, a condition in which there is an exaggerated response by the body to the stimulus of a foreign agent.
2. In endocrinology, an excessive target tissue response to a hormone. Synonym(s): hormone hypersensitivity


Immunology An abnormal immune response that may be immediate–due to antibodies of the IgE class, or delayed–due to cell-mediated immunity. See Cold hypersensitivity, Immediate hypersensitivity Neurology Exaggerated sensitivity An ↑in a person's sensitivity to light, sound, smell, taste, touch, temperature, balance, and even emotional issues, which may be linked to anxiety and panic disorders.


Abnormal sensitivity, a condition in which there is an exaggerated response by the body to the stimulus of a foreign agent.
See: allergy


An allergic state in which more severe tissue reactions occur on a second or subsequent exposure to an ANTIGEN than on the first exposure. A particular group of antibodies (IgE) is involved in many hypersensitivity reactions.


the process of localized plant cell death that occurs immediately after entry of a cell by a plant pathogen. Such a reaction can act as a host-resistance mechanism since the cell death often prevents further growth of biotrophic pathogens, e.g. powdery mildews or rusts.


After the body's immune system attacks an outside invader (such as organic dust or a fungus) many times, exposure to even a tiny amount of this allergen can provoke a strong inflammatory response.


An excessive reaction, local or systemic, or inappropriate immune response to an antigen. Four types of immune responses are usually described, but the main reaction involving the eyes is type 1. They are also called allergic reactions types 1-4.
type 1 hypersensitivity An immediate, abnormal reaction occurring when an antigen reacts with an antibody (e.g. immunoglobulin E (IgE)) attached to a mast cell or basophil. This leads to the release of specific chemical mediators of allergy (e.g. histamine) that react with target organs throughout the body. Systemic signs include: itching, lacrimation, skin rash and possibly haemodynamic collapse and shock. Allergic conjunctivitis is an example of this type of hypersensitivity.
Type 2 h . (cytotoxic h.) is caused by an interaction of antibody and antigens on cell surfaces. Examples: Graves' disease, myasthenia gravis. Type 3 h. (immune-complex mediated h.) is mediated by a combination of antigen-antibody. Example: systemic lupus erythematosus. Type 4 h. (T cell-mediated h.) is a delayed reaction (several days to develop) mediated by T lymphocytes. Example: rheumatoid arthritis. See antihistamine; mast cell stabilizers.


In endocrinology, an excessive target tissue response to a hormone.

Patient discussion about hypersensitivity

Q. ALLERGIES what are they,who gets them,are they caused by pollen and food?

A. Allergy is the exaggerated and out-of-place reaction of the immune system to external substances or stimuli that are not harmful to the body, so the reaction actually damages the body instead of helping it.

The may be pollen and foods, as well as insect stings, drugs and almost any other substances.

You may read more here:

Q. what is the most common allergy? is it dust allergy?

A. thanks, I've heard of a new allergy treatment and trying to learn some more about the different kinds...

Q. what are the symptoms of Allergy?

A. from you question i understand that you think you might developed an allergy. so here is a web page with couple of videos explaining about allergies:

More discussions about hypersensitivity
References in periodicals archive ?
The results of the presented research indicate that in individuals presenting anaphylactic symptoms in their medical history, such as intensified urticaria, angioedema and rhinitis, the risk of confirming the immunological background of lidocaine hypersensitivity is higher.
Treating dentinal hypersensitivity can be challenging for the dental professional because of the difficulty related to measuring the pain response.
The hypersensitivity after cementation procedure also happens very commonly and is a huge challenge for dentists.14,15 This study aimed at exploring the management of post cementation sensitivity done by dentists and their opinion regarding the preventive factors of hypersensitivity.
In view of the foregoing, the main objective of this study was to evaluate and compare the application of diode laser 940 Nm vs 5 % potassium nitrate as potential treatments for dentin hypersensitivity (DH).
Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites.
Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses.
Although sugammadex is a safe, effective, lifesaving, and gold standard agent, it is necessary to be careful, particularly in the first 5 min after administration, because it can lead to life-threatening hypersensitivity reactions.
Use of mycophenolate mofetil or azathioprine for the management of chronic hypersensitivity pneumonitis [published online ahead of print November 2, 2016].
Here, the rat model of visceral hypersensitivity was induced by repetitive WAS and was assessed by CRD test.
Mechanical Hypersensitivity. Mechanical hypersensitivity was assessed using von Frey filaments (Touch-Test[TM] Sensory Evaluators, Linton Instrumentation, UK) as previously described [20-22, 24].
Biopsy of the pustule showed suppurative folliculitis, which is expected from a neutrophil driven process, consistent with azathioprine hypersensitivity (Figure 2).
Delayed-type reactions consist primarily of type IV reactions, which are T cell-mediated delayed-type drug hypersensitivity reactions.

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