hypersegmented neutrophil

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hy·per·seg·ment·ed neu·tro·phil

an aged and degenerated neutrophil in which there may be 6-10 lobes in the nucleus.


1. one of the three granular leukocytes having a nucleus with three to five lobes connected by threads of chromatin, and cytoplasm containing lysosomes that stain characteristically and enable neutrophils to be distinguished from basophils and eosinophils; called also a granulocyte or polymorphonuclear leukocyte. See also heterophil (1).
2. any cell, structure or histological element readily stainable with neutral dyes.

band neutrophil
see stab neutrophil (below).
neutrophil chemotactic factor
hypersegmented neutrophil
increased number of nuclear lobes; seen in hyperadrenocorticism or during treatment with corticosteroids, and in blood that has been in transit for long periods.
hyposegmented neutrophil
a lack of nuclear lobes; may occur in chronic infections and is a feature of pelger-huet anomaly.
neutrophil:lymphocyte ratio
correlates directly with the magnitude of the total leukocyte count in response to disease in domestic animals; it varies from 0.5 in cattle to 3.5 in dogs.
stab neutrophil
a neutrophilic leukocyte whose nucleus is not divided into segments.
toxic neutrophil
one with blue-black or large reddish cytoplasmic granules and diffuse cytoplasmic basophilia and vacuolation; caused by disruption of maturation.
References in periodicals archive ?
According to Thompson et al, in 91% of 515 patients, hypersegmented neutrophil was a more sensitive indicator as compared to MCV.
Hence, in rural areas where higher end equipment is not available, a simple peripheral smear staining would help in identification of hypersegmented neutrophil in alcoholic patients.
Hypersegmented Neutrophil in Cases and Control Population
12] above 200pg /ml--six were between 200 and 300 pg/ml and nine, macrocytosis with hypersegmented neutrophils were seen in six patients and raised LDH (sign.
Megaloblastosis is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow [Figure 4] and also by hypersegmented neutrophils having five or more nuclear lobes in more than 5% of cells in the peripheral smears