Airway inflammation leads to increased bronchial contractions termed airway hyperresponsiveness
(AHR) and asthmatic symptoms such as wheezing, shortness of breath, and chest tightness .
[sup] As a glycoprotein that stimulates the endothelial cell proliferation and neoangiogenesis, VEGF may contribute to bronchial inflammation, hyperresponsiveness
, and vascular remodeling in those patients.
Murine OVA models show that pretreatment with ADMA enhances allergic airway inflammation, bronchial hyperresponsiveness
, and airway remodeling [9, 28].
These findings demonstrate that both ASC and caspase1 play a dominant role in airway hyperresponsiveness
and suggest a functional role for the alveolar macrophages as an important source of proinflammatory cytokines.
is characteristic of asthma and is related to the degree of airway inflammation.
Asthma is characterized by variable airflow obstruction with airway hyperresponsiveness
; prominent clinical manifestations include wheezing and shortness of breath.
As so little is known about that epigenetic regulation of MBD2 in both immunological pathogenesis of experimental severe asthma and [CD4.sup.+] T cell differentiation, they first aimed to establish a neutrophil-predominant severe asthma model, characterized by airway hyperresponsiveness
(AHR), BALF neutrophil granulocyte (NEU) increase, higher NEU and IL-17 protein levels, and more Th17 cell differentiation.
Asthma is associated with airway hyperresponsiveness
(AHR), which leads to recurrent episodes of shortness of breath, coughing, and wheezing.
Obesity has been shown to influence a number of signaling pathways involved in inflammation and airway hyperresponsiveness
Although bromine is less reactive and oxidative than chlorine, inhalation also results in bronchospasm, airway hyperresponsiveness
, ARDS, and even death.
causes the airways to narrow, obstructing ease of breathing, and can occur when the muscles contract or begin to spasm.
Pathobiologically, asthma is characterized by a complex chronic inflammation that causes airway remodeling and hyperresponsiveness
of bronchial smooth muscles.