Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity
. J Immunol 2010;185:5225-35.
Although asthma is not curable, advancements have enabled an evolution in pharmacologic interventions, which form the mainstay of asthma management because they reduce airway inflammation and airway hyperreactivity
. (1) These medications can be categorized as controller medications, which reduce inflammation and exacerbation risk, and reliever medications, which alleviate bronchospasm and acute symptoms.
in patients with idiopathic spasmodic torticollis.
In the study of Pincus-Knackstedt et al., when stress to the mother during the gestational stage and an OVA sensitization to the offspring were observed, an inflammation of atopic characteristics was observed, specifically in the submucosa area of the airway, and muscle hyperreactivity
in the offspring of prenatally stressed mothers.
One intriguing mechanism that has been proposed is that pressor hyperreactivity
is a manifestation of a widespread basic membrane transport disorder that disrupts cellular cation homeostasis.
Effect of high thoracic epidural anesthesia and local anesthetic on bronchial hyperreactivity
. J Clin Monit Comput 2000;16(5-6):457-63.
Furthermore, we found that the development of airway hyperreactivity
and Th2-related pulmonary inflammatory responses were inhibited in mice treated with an antigen OK-432 formula prior to allergen challenge.
[17, 18] have showed that the contractile carotid hyperreactivity
underlying cerebrovascular complication in stressed diabetic animals involves the upregulation of NADPH/Nox4 oxidase-driven generation of hydrogen peroxide ([H.sub.2][O.sub.2])  and inducible nitric oxide synthase (iNOS)-driven generation of peroxynitrite (ONOO-) .
In addition, TMAO has an effect on platelet activation, inducing platelet hyperreactivity
leading to a prothrombotic effect and promoting thrombus formation .
Increased number of platelet aggregates in circulation, increased aggregation of platelets after platelet agonists' addition, increased platelet contractility, and presence of elevated plasma levels of their contents [beta-thromboglobulin, platelet factor 4, thromboxane [B.sub.2]), demonstrate platelet hyperreactivity
Finally, bronchial hyperreactivity
in CHF may play a significant role.
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity
, and lung damage in a mouse asthma model.