Vessby, "Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia
in obese men," Diabetes Care, vol.
Fasting hyperinsulinemia, hyperproinsulinemia, high FPI/SI ratio, and IR were defined by >95th percentile of our healthy reference population; that is, FSI > 11.8 mIU/L, FPI > 9.8pmol/L, FPI/SI > 25%, and HOMA-IR > 2.54.
To further compare the IR and [beta]-cell dysfunction among groups, we set the 95th percentile in normal group as the cutoff point to identify subjects with fasting hyperinsulinemia, hyperproinsulinemia, high FPI/TI ratio, and high HOMA-IR.
Two major hypotheses have been expounded to explain the hyperproinsulinemia
in type 2 diabetes: the increased release of proinsulin might result from an intrinsic defect in proinsulin processing, leading to an increased release of immature insulin precursors and thus contributing to the impairment in [beta]-cell function in type 2 DM.
segregates young adult patients with newly diagnosed autoimmune (type 1) and non-autoimmune (type 2) diabetes.
is a common feature of the insulin resistance (IR) syndrome.
In this study, total proinsulin concentrations were in accord with previously published reports of 10% (proinsulin:insulin) for samples from persons without diabetes and 20% for patients with type 2 diabetes (24), with no samples displaying inappropriate hyperproinsulinemia (25).
A novel point mutation in the insulin gene giving rise to hyperproinsulinemia. J Clin Endocrinol Metab 1997;82:1629-31.
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia
in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Consequently, it seems of greater clinical utility to quantify the consequences of the insulin resistance and hyperinsulinemia (or hyperproinsulinemia
) rather than the hormone values themselves, i.e., by measuring blood pressure, degree of glucose tolerance, and plasma triglyceride and HDL-cholesterol concentrations.
However, in patients suffering from type I (10) or type II diabetes (11-13), familial hyperproinsulinemia
(14,15), or insulinoma (16), the insulin concentration can be overestimated by the relatively high concentrations of proinsulin and conversion intermediates.
Proinsulin-like material is increased in clinical conditions such as insulinoma (6-9), familial hyperproinsulinemia
(10-13), and non-insulin-dependent diabetes mellitus (NIDDM) (3,9,14-17).