hyperproinsulinemia


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hy·per·pro·in·su·li·ne·mi·a

(hī'pĕr-prō-in'sŭl-i-nē'mē-ă),
Elevated plasma levels of proinsulin or proinsulinlike material.

hy·per·pro·in·su·li·ne·mi·a

(hī'pĕr-prō-in'sŭl-i-nē'mē-ă)
Elevated plasma levels of proinsulin or proinsulinlike material.
Synonym(s): hyperproinsulinaemia.
References in periodicals archive ?
Vessby, "Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men," Diabetes Care, vol.
Fasting hyperinsulinemia, hyperproinsulinemia, high FPI/SI ratio, and IR were defined by >95th percentile of our healthy reference population; that is, FSI > 11.8 mIU/L, FPI > 9.8pmol/L, FPI/SI > 25%, and HOMA-IR > 2.54.
To further compare the IR and [beta]-cell dysfunction among groups, we set the 95th percentile in normal group as the cutoff point to identify subjects with fasting hyperinsulinemia, hyperproinsulinemia, high FPI/TI ratio, and high HOMA-IR.
Two major hypotheses have been expounded to explain the hyperproinsulinemia in type 2 diabetes: the increased release of proinsulin might result from an intrinsic defect in proinsulin processing, leading to an increased release of immature insulin precursors and thus contributing to the impairment in [beta]-cell function in type 2 DM.
Hyperproinsulinemia segregates young adult patients with newly diagnosed autoimmune (type 1) and non-autoimmune (type 2) diabetes.
In this study, total proinsulin concentrations were in accord with previously published reports of 10% (proinsulin:insulin) for samples from persons without diabetes and 20% for patients with type 2 diabetes (24), with no samples displaying inappropriate hyperproinsulinemia (25).
A novel point mutation in the insulin gene giving rise to hyperproinsulinemia. J Clin Endocrinol Metab 1997;82:1629-31.
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Consequently, it seems of greater clinical utility to quantify the consequences of the insulin resistance and hyperinsulinemia (or hyperproinsulinemia) rather than the hormone values themselves, i.e., by measuring blood pressure, degree of glucose tolerance, and plasma triglyceride and HDL-cholesterol concentrations.
However, in patients suffering from type I (10) or type II diabetes (11-13), familial hyperproinsulinemia (14,15), or insulinoma (16), the insulin concentration can be overestimated by the relatively high concentrations of proinsulin and conversion intermediates.
Proinsulin-like material is increased in clinical conditions such as insulinoma (6-9), familial hyperproinsulinemia (10-13), and non-insulin-dependent diabetes mellitus (NIDDM) (3,9,14-17).