Why is the
hyperplastic polyp a marker for precancerous condition of the gastric mucosa.
Histopathology, Immunohistochemistry, and Molecular Characteristics.--Most duodenal
hyperplastic polyps reported so far in the literature (14 of 16 cases; 87.5%) have the histologic appearance of a microvesicular
hyperplastic polyp of the large bowel, characterized by hyperplastic, columnar microvesciular mucinous epithelium with luminal and crypt serration lacking cytologic atypia (Figure 4, A).
KEYWORDS: Clinical and Pathological Features, Colorectal Serrated Polyps,
Hyperplastic Polyp, Sessile Serrated Adenoma/Polyp.
Microscopic examination of the nonadenomatous polyps (n=27) led to a variety of findings duodenitis/inflammatory polyp (n=10), normal duodenal tissue (n=7), gastric heterotopia (n=4), Brunner's gland hyperplasia (n=2),
hyperplastic polyp (n=1), leiomyoma (n=1), lipoma (n=1), and vascular ectasia consistent with portal hypertensive duodenopathy (n=1).
Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in
hyperplastic polyp and sessile serrated polyp/adenoma.
Serrated lesions were categorized as
hyperplastic polyp, sessile serrated adenoma and traditional serrated adenoma.
Regarding serrated polyps, there are three types of polyps such as
hyperplastic polyp, traditional serrated adenoma (TSA), and SSA/P [27].
Biopsy of the stricture was taken which proved pathologically to be a benign
hyperplastic polyp.
On the other hand, we present three cases that I know my colleagues read with interest and which never lose their popularity:
hyperplastic polyp of the appendix, traumatic sigmoid colon perforation, and endoscopic removal of a foreign body in a rare and intriguing patient with situs inversus totalis.
Its concomitant occurrence with
hyperplastic polyp has never been reported.
The proportions of
hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA) of all serrated polyps were 41.2%, 7.2%, and 51.6%, respectively, which showed a lower proportion of HP and SSA/P and a higher proportion of TSA.
These diagnoses included the following: melanosis coli (in 4 specimens with tubular adenomas and 1 specimen with
hyperplastic polyp), mucosal prolapse (in 2 specimens with
hyperplastic polyps), schistosomiasis (Figures 4(a), 4(b), and 4(c)) (in 1 specimen with adenocarcinoma and 1 specimen with
hyperplastic polyp), and intestinal spirochetosis (Figure 5) (in 1 specimen with sessile serrated adenoma), and they were confirmed retrospectively by both of us.
