Persistent hypotonia led to diagnosis 8 y (7 d) Very foppy and difficult to feed at birth,
hyperphagic from 3 years 9 y (4 w) Bruised at birth.
Models of
hyperphagic birds have shown the negative effect of overfeeding in both sexes, while a dietary restriction during their growth increases oviposition rates and the duration of the fertile period.
These mice have APL features, but do not express insulin resistance unless crossed with severely
hyperphagic leptin-deficient ob/ob mice.
ADMR and FMR were developed for birds during the breeding season and therefore underestimates food requirements and consumption when birds are
hyperphagic [54].
Ob/ob and db/db mice that lack leptin or are leptin resistant, respectively, are profoundly
hyperphagic and hypometabolic, leading to an obese phenotype, and they manifest numerous abnormalities, such as type 2 diabetes with severe insulin resistance, hypothermia and cold intolerance, infertility, and decrease in lean (21), (22).
Adiponectin is regulated differently by chronic exercise than by weight-matched food restriction in
hyperphagic and obese OLETF rats.
We have previously shown that hepatic mitochondrial dysfunction is a significant contributing factor to NAFLD development and progression in the
hyperphagic, obese Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a commonly studied model of insulin resistance and type 2 diabetes [7].
Those with leptin deficiency have the greatest energy intake, those with inactive MC4R mutations are less
hyperphagic, and those with partially active mutations have similar intake to those with treated leptin deficiency [27].
Uptergrove et al., "Exercise and omega-3 polyunsaturated fatty acid supplementation for the treatment of hepatic steatosis in
hyperphagic OLETF rats," Journal of Nutrition and Metabolism, vol.
We also (4) assess whether the sea ice concentration in spring, when polar bears are
hyperphagic (Stirling, 2002), has been declining.
To maintain a healthy weight comfortably, it is important to interrupt and block this sabotaging
hyperphagic cycle.
The majority of studies conducted on the effect of cannabis and/or various cannabinoid administrations on food intake in animals, have either failed to find an effect on eating behaviour, or found that cannabinoids induced an anorectic or
hyperphagic effect (Pagotto et al.