hyperoxia test

hyperoxia test

The administration of 100% oxygen to a patient (typically a neonate) to determine the cause of respiratory distress, hypoxemia, cyanosis, and/or shock. The resolution of cyanosis with treatment usually indicates that the cause of the hypoxia is a lung disease, e.g., pneumonia. If the PaO2 at the conclusion of the test is > 150 torr, cardiac disease can usually be excluded. Failure of neonates to respond to 100% oxygen is usually an indication of severe congenital heart disease.
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Factors considered in the diagnosis included differential oxygen saturation [greater than or equal to] 10% (difference between preductal and postductal) or difference in arterial P[O.sub.2] [greater than or equal to] 20 mmHg, hypoxaemia disproportionate to the chest X-ray changes and unresponsiveness to a hyperoxia test. Owing to limited capacity of paediatric cardiologists at CMJAH, echocardiography to confirm PPHN was performed only in selected cases.
Supplemental tests could include basic metabolic panel, electrocardiogram, blood cultures, and a hyperoxia test. In particular, the hyperoxia test can be of notable importance because it can help to determine between a cardiac and pulmonary etiology of hypoxemia.