hyperoxaluria


Also found in: Encyclopedia, Wikipedia.

hyperoxaluria

 [hi″per-ok″sah-lu´re-ah]
an excess of oxalates in the urine, which can lead to formation of kidney stones. Called also oxaluria.
enteric hyperoxaluria formation of calcium oxalate calculi in the urinary tract, occurring after extensive resection or disease of the ileum, due to excessive absorption of oxalate from the colon.
primary hyperoxaluria an autosomal recessive disorder characterized by urinary excretion of oxalate, with nephrolithiasis, nephrocalcinosis, early onset of renal failure, and often a generalized deposit of calcium oxalate.

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok'să-lyū'rē-ă),
Presence of an unusually large amount of oxalic acid or oxalates in the urine; renal stones may occur.
Synonym(s): oxaluria

hyperoxaluria

/hy·per·ox·al·uria/ (-ok″sah-lu″re-ah) an excess of oxalates in the urine.
enteric hyperoxaluria  formation of calcium oxalate calculi in the urinary tract after resection or disease of the ileum, due to excessive absorption of oxalate from the colon.
primary hyperoxaluria  an inborn error of metabolism with defective glyoxylate metabolism, excessive urinary excretion of oxalate, nephrolithiasis, nephrocalcinosis, early onset of renal failure, and often a generalized deposit of calcium oxalate.

hyperoxaluria

(hī′pər-ŏk′sə-lo͝or′ē-ə)
n.
The presence of an unusually large amount of oxalic acid or oxalates in the urine.

hyperoxaluria

[-ok′səloo͡r′ē·ə]
an excessive level of oxalic acid or oxalates, primarily calcium oxalate, in the urine. The cause is usually an inherited deficiency of an enzyme needed to metabolize oxalic acid, which is present in many fruits and vegetables, or a disorder of fat absorption in the small intestine. An excess of oxalates may lead to the formation of renal calculi and renal failure. Treatments include pyridoxine, forced fluids, and a low-oxalate diet.

hyperoxaluria

A condition characterised by excess urinary oxalate (formula C2O4), which may lead to calcium oxalate stones in the pelvicalyceal system or urinary bladder.

Aetiology
Acute tubular necrosis, enteric hyperoxaluria, cystic fibrosis, coeliac disease, diabetes, foods (e.g., beef greens, rhubarb, spinach, beets, chard, okra, peanuts, chocolate, pecans, tea, carrots), short bowel syndrome.

Management, primary hyeroxaluria
High-dose pyridoxine, orthophosphate, magnesium, increased fluid volumes, glycosaminoglycans (pentosan polysulfate), dialysis.

Management, secondary hyeroxaluria
Calcium supplements, iron, aluminium, magnesium, potassium citrate, cholestyramine, diet (reduced fat, low meat, low oxalate foods).

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok-să-lyūr'ē-ă)
Presence of an unusually large amount of oxalic acid or oxalates in the urine.
Synonym(s): oxaluria.

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok-să-lyūr'ē-ă)
Presence of an unusually large amount of oxalic acid or oxalates in the urine.
Synonym(s): oxaluria.

hyperoxaluria (hī´pərok´səlŏŏr´ēə),

n an excessive level of oxalic acid or oxalates, primarily calcium oxalate, in the urine. The cause is usually an inherited deficiency of an enzyme needed to metabolize oxalic acid, which is present in many fruits and vegetables, or a disorder of fat absorption in the small intestine. An excess of oxalates may lead to the formation of renal calculi. Treatment may include pyridoxine, forced fluid, and a low-oxalate diet.
hyperoxaluria, primary,
n an inherited deficiency of the enzyme that metabolizes oxalic acid, resulting in an excessive level of oxalic acid or oxalates in the urine.

hyperoxaluria

an excess of oxalate in the urine; occurs in dogs in association with oxalate urolith formation.

primary hyperoxaluria
inherited metabolic defect in cats. Characterized by heavy deposits of oxalates in renal tubules, leading to oxalate nephrosis and fatal uremia before the patient reaches a year of age.
References in periodicals archive ?
We believe that our approach has the potential of enhancing the quality of life of many who suffer from oxalate-related conditions, including primary hyperoxaluria, kidney stones, enteric hyperoxaluria, and cystic fibrosis," said Dr.
based Ixion is the world's leader in developing diagnostic and prevention options for oxalate-related disorders, such as kidney stones, primary hyperoxaluria, Crohn's Disease, and cystic fibrosis.
The absence of Oxf from the GI-tract may be a risk factor for the development of hyperoxaluria and calcium oxalate kidney stones.
Primary Hyperoxaluria is a rare, autosomal recessive disease, caused by deficiency of an enzyme in the liver, affecting approximately 3,000 to 4,000 children and adolescents.
After induction of hyperoxaluria, urinary oxalate excretion in the Pyridorin treated group decreased by about 50% compared to untreated controls.
Another clinical setting characterized by calcium oxalate nephrolithiasis is primary hyperoxaluria, a rare inherited metabolic disorder associated with early-onset renal failure and death.
Since dietary oxalate intake accounts for such a small amount of the oxalates actually found in the urine of people who form calcium oxalate stones, it is now fairly well accepted that dietary restriction of oxalate-containing foods is not a viable therapeutic intervention to prevent stone formation, except in a few rare circumstances: hypercalciuria type II and hyperoxaluria (primary and enteric).
We examined the percentage of patients with hypercalciuria (>260 mg/24-h), hyperoxaluria (>40 mg/24-h), hypocitraturia (<320 mg/24-h), and hyperuricosuria (>750 mg/24-h).
NASDAQ: DRNA) for exclusive use in Dicerna's primary hyperoxaluria type 1 (PH1) development program.
OxThera is currently pursuing a complete clinical development program in the EU and in the US for the treatment of patients suffering from Primary Hyperoxaluria.
Purpose: To increase the surface area of hemofiltration during dialysis in an attempt to significantly reduce oxalate levels in a patient with primary hyperoxaluria.