AnaptysBio's SHM-XEL platform has pioneered the use of in vitro somatic hypermutation
for antibody discovery, which is designed to replicate key features of the human immune system and overcomes limitations of prior antibody technologies.
Affinity maturation, hypermutation
and receptor editing are critical processes of the immune systems.
However, some lower eukaryotes that evolved before the emergence of immunity also possess specialised polymerases, indicating that they did not all evolve primarily to support somatic hypermutation
or class switching.
In all the cases with 2 clonal amplification products in the same tube, the difference in size between the amplicons was greater than a few nucleotides, making the possibility that the separate amplicons were the result of somatic hypermutation
This somatic hypermutation
results in a highly responsive pool of B-cells that can be reactivated much more rapidly on the next encounter with their antigen.
Epidemiological evidence and indirect molecular findings from immunoglobulin heavy chain variable region gene studies suggest that chronic persistent antigen stimulation constitutes a significant pathogenetic mechanism of thyroid NHL (6), (7) Aberrant activity of somatic hypermutation
is another mechanism which may contribute to the development of lymphoid malignancies by causing genetic instability and favouring chromosomal translocation (8).
The neoplastic cells in PEL lack surface expression of B-cell markers, such as CD19, CD20, CD79a, and immunoglobulin, they express plasma cell-related markers, such as CD30, CD38, CD45, and CD138, but they also exhibit clonal rearrangement and somatic hypermutation
of immunoglobulin genes, suggesting that they originate from post-germinal center B-cells (1), (5), (6), (7).
is, in part, responsible, for affinity maturation during an immune response.
H] families, which have also undergone somatic hypermutation
Among its other findings, this study is the first to find that the genomes of breast carcinomas bear regional clusters of hypermutation
, termed "kataegis," and that these regions display a prevalence of signature B mutations.
as a factor contributing to the acquisition of antimicrobial resistance.
Meyerhans A, Asjo B, Wain-Hobson S: Selection, Recombination, and G A Hypermutation
of Human Immunodeficiency Virus Type 1Genomes: JV (April) 1991: 1779-1788.