It is likely that neostigmine used at reversal precipitated hypermotility
of the small bowel in the above patient.
* Anticholinergics/antispasmodics: These agents have been used for many years for peptic ulcer and functional GI disorders such as diarrhea, hypermotility
, neurogenic colon, irritable bowel syndrome, ulcerative colitis, biliary tract spasm, and similar conditions.
Although hypomotilily is the leading cause of dysphagia, some cases are caused by the opposite problem: the inability of the patient's body to inhibit muscular contraction in the esophagus, resulting in hypermotility
or spastic disorders.
Diarrhea that never awakens the patient from sleep is often caused by bowel hypermotility
. Malabsorptive diarrhea should abate with fasting.
Acute toxic manifestations of cholinergic crisis caused by nerve agents are similar to those caused by organophosphates, which include increased sweating and bronchial, salivary, ocular, and intestinal secretions; "pinpoint" pupils (miosis); intestinal hypermotility
; bronchospasms; and bradycardia (11-13).
Ictal phenomena which involve the autonomic system are primarily mediated by the insular cortex and the amygdala region with its connections to the hypothalamus, as well as the opercular, mesial and orbito-frontal regions. Sensations of nausea, butterflies in the stomach, gastrointestinal hypermotility
or a rising sensation in the epigastric region are among the most common symptoms with significant localization to the right temporal lobe. Other autonomic phenomenon are more discernible and include pupillary changes, irregular respiratory and cardiac patterns, facial flush or a rash, and piloerection.
CBD does not modify intestinal motility in control animals, but can inhibit the hypermotility
associated to experimental ileitis in mice (37).
This assumption is suported by PEARSON (1971), who reports that distention of intestinal segments, enteritis, alterations in intestinal motility, hypomotility or hypermotility
, are considered predisposing factors for the development of intussusception in cattle.
Complications of mast cell disease in domestic animals include gastroduodenal ulceration secondary to histamine release and subsequent stimulation of gastric H2 receptors, excessive acid secretion, and hypermotility
. Additional complications include pruritus, prolonged coagulation times, and delayed healing of surgical sites.
Effects of molsidomine on scopolamine-induced amnesia and hypermotility
in the rat.
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility
of the rumen, resulting in the reflux of its content, is due to the action of the plants' grayanotoxin on the muscarinic and nicotinic cholinergic receptors (ARMIEN et al., 1995).