al and Darmon et al in which 70% and 63.8% of children with acute leukemia had TLS.15,18 However, high figures in our study may be due to the most common malignant condition associated with very high leukemic burden, hyperleukocytosis
It addresses the causes and risk factors for each, the initial and confirmatory diagnostic tests, and treatment options, as well as the basics of blood and its components; the pathophysiology and classification of leukemias; epidemiology; etiology; staging and general management; supportive care; and emergencies like neutropenic sepsis, coagulopathy, tumor lysis syndrome, hyperleukocytosis
and leukostasis, differentiation syndrome, and asparaginase-related thromboses.
In ALL patients, like our case, hyperleukocytosis
at administration, Philadelphia chromosome positivity show poor prognosis.
Our patient had hyperleukocytosis
and features consistent with low-flow.
Transient leukemoid reactions (TLR) are well-documented in the neonatal intensive care unit and have been associated with antenatal corticosteroid usage, perinatal infections, chorioamnionitis, and Down syndrome [1-9] The incidence varies between 1.3% and 15% [1-2, 10-12] however, extreme hyperleukocytosis
which is defined as a white blood cell (WBC) count of >100 x [10.sup.9]/L is a rare entity in premature neonates .
This young adult presented with acute respiratory distress after catheterization, accompanied with hypoxemia, hypercarbia, tachycardia, neutrophil-predominant hyperleukocytosis
, and bilateral diffuse intensity on chest X-ray (Figure 2).
Complete blood count showed hyperleukocytosis
(white blood cell count (WBC) of 110 bil/L with 33% blasts) and severe anemia (hemoglobin of 4.0 g/dL).
Adult-onset Still's disease (AOSD) is an auto-inflammatory disorder, characterized by spiking fevers, evanescent salmon-pink rash, arthritis or arthralgia, and hyperleukocytosis
. (1) The pathogenesis remains unknown, but infection may be a trigger in a genetically susceptible host.
A 6-year-old boy was admitted because of T-cell acute lymphocytic leukemia with hyperleukocytosis
. Treatment with corticosteroids was started immediately.
Hematopathology review of the peripheral blood revealed a hyperleukocytosis
with absolute neutrophilia and a peripheral blast count of 2%.
A complete blood count revealed a hyperleukocytosis
of 42000/ml, moderate anemia with a hemoglobin level of 8.2g/ml, and a normal platelet count.
AGEP and generalized pustular psoriasis (GPP) share common clinical manifestations: diffuse pustules over the entire body and systemic symptoms of high fever and neutrophil-predominant hyperleukocytosis