Lack of a statistically significant relation between serum leptin levels and platelet aggeregation parameters in our PD patients might be explained by leptin receptor downregulation or disturbed postreceptor cytoplasmic pathways leading to resistance developped againist NO-like effects seen in chronic hyperleptinemia
as sugeste by the literature.
A number of studies also showed the relationship between hyperleptinemia
and MAU and GFR decline .
As shown in Table 1, hyperleptinemia
was detected in fructose fed mice (p<0.
Other factors that contribute to oxidative stress in obesity are abnormal postprandial glucose, hyperleptinemia
, chronic inflammation, tissue dysfunction, and low antioxidant defense (Furukawa et al.
as a component of a metabolic syndrome of cardiovascular risk.
As expected , MSG rats displayed severe hyperleptinemia
(P < 0.
Moreover, subcutaneous adipocyte size is associated with plasma leptin concentrations independent of total adiposity, suggesting that hyperleptinemia
in obesity is likely a function of both subcutaneous adipocyte hypertrophy and hypersecretion.
of aging explains why diets fail Americans who are eating less calories as they age but still gaining weight.
The variations of leptin receptor gene have been identified and these result in the development of the leptin resistance leading to a state of hyperleptinemia
and obesity .
Induction of obesity and hyperleptinemia
by central glucocorticoid infusion in the rat.
The observations that starvation decreases both plasma insulin and leptin levels and that obesity is strongly associated with hyperinsulinemia and hyperleptinemia
have led many researchers to investigate the effects of insulin on leptin secretion.
Leptin and hyperleptinemia
from friend to for cardiovascular function.