vascular adhesion (iii) Therapeutic molecules, and investigations for prothrombotic tissue hyperleptinemia
are still factor.
Considering that leptin promotes lipolysis, reducing TG uptake by adipocytes (38), hyperleptinemia
probably increased serum TG levels in the obese rats.
When free-leptin concentrations are compared between lean and obese individuals, even more pronounced hyperleptinemia
in obesity is observed than that reported by measuring total leptin concentrations.
Furthermore longitudinal studies in young Japanese adults reveal elevations in plasma noradrenaline levels precede both weight gain and increases in plasma leptin levels [29, 61] suggesting hyperleptinemia
is ancillary to sympathetic stimulation associated with obesity.
. Leptin, WAT-derived hormone, has been shown to increase the generation of ROS in endothelial cells [125,126].
Sanches et al., "Hyperleptinemia
in obese adolescents deregulates neuropeptides during weight loss" Peptides, vol.
2008), or whether the observed hyperleptinemia
is a consequence of the altered metabolic state of these animals.
Thus, because circulating leptin levels are not increased during postprandial hyperinsulinemia or during euglycemic (or hypoglycemic) hyperinsulinemia, we conclude that, at least in the short term, insulin does not increase leptin secretion in humans and that hyperleptinemia
in obese individuals is not likely the result of hyperinsulinemia.
of pregnancy associated with the appearance of a circulating form of the leptin receptor.
There is much controversial data, but most clinical studies support that during pregnancy, insulin resistance and hyperinsulinemia promote adipocyte leptin synthesis that is independent of maternal BMI and further suggest an association of early hyperleptinemia
with later GDM onset [2, 4].
Given that Zucker rats are genetically defective in the leptin receptor and consistently present hyperleptinemia
, such effects may be caused by chronic myocyte stimulation by leptin.
Kalra, "Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia
, and hyperinsulinemia: increase in serum ghrelin levels," Diabetes, vol.