hyperleptinemia


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hyperleptinemia

(hī″pĕr-lĕp″tĭn-ē′mē-ă) [″ + ″ + ″]
Excess levels of leptin in the blood. Hyperleptinemia increases body fat content and stimulates appetite.
References in periodicals archive ?
Lack of a statistically significant relation between serum leptin levels and platelet aggeregation parameters in our PD patients might be explained by leptin receptor downregulation or disturbed postreceptor cytoplasmic pathways leading to resistance developped againist NO-like effects seen in chronic hyperleptinemia as sugeste by the literature.
A number of studies also showed the relationship between hyperleptinemia and MAU and GFR decline [8].
Other factors that contribute to oxidative stress in obesity are abnormal postprandial glucose, hyperleptinemia, chronic inflammation, tissue dysfunction, and low antioxidant defense (Furukawa et al.
Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk.
As expected [27], MSG rats displayed severe hyperleptinemia (P < 0.
Moreover, subcutaneous adipocyte size is associated with plasma leptin concentrations independent of total adiposity, suggesting that hyperleptinemia in obesity is likely a function of both subcutaneous adipocyte hypertrophy and hypersecretion.
Hyperleptinemia of aging explains why diets fail Americans who are eating less calories as they age but still gaining weight.
The variations of leptin receptor gene have been identified and these result in the development of the leptin resistance leading to a state of hyperleptinemia and obesity [26].
The observations that starvation decreases both plasma insulin and leptin levels and that obesity is strongly associated with hyperinsulinemia and hyperleptinemia have led many researchers to investigate the effects of insulin on leptin secretion.